Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/364054
Type: Artigo
Title: Kinetic profile of N,N-dimethyltryptamine and β-carbolines in saliva and serum after oral administration of ayahuasca in a religious context
Author: Lanaro, Rafael
Mello, Sueli Moreira
Cunha, Kelly Francisco
Silveira, Gabriela
Corrêa‐Neto, Nelson Francisco
Hyslop, Stephen
Cabrices, Oscar G.
Costa, Jose Luiz
Linardi, Alessandra
Abstract: Ayahuasca is a beverage obtained from Banisteriopsis caapi plus Psychotria viridis. B. caapi contains the β-carbolines harmine, harmaline, and tetrahydroharmine that are monoamine oxidase inhibitors and P. viridis contains N,N-dimethyltryptamine (DMT) that is responsible for the visionary effects of the beverage. Ayahuasca use is becoming a global phenomenon, and the recreational use of DMT and similar alkaloids has also increased in recent years; such uncontrolled use can lead to severe intoxications. In this investigation, liquid chromatography–tandem mass spectrometry (LC–MS/MS) was used to study the kinetics of alkaloids over a 24 h period in saliva and serum of 14 volunteers who consumed ayahuasca twice a month in a religious context. We compared the area under the curve (AUC), maximum concentration (Cmax), time to reach Cmax (Tmax), mean residence time (MRT), and half-life (t1/2), as well as the serum/saliva ratios of these parameters. DMT and β-carboline concentrations (Cmax) and AUC were higher in saliva than in serum and the MRT was 1.5–3.0 times higher in serum. A generalized estimation equations (GEEs) model suggested that serum concentrations could be predicted by saliva concentrations, despite large individual variability in the saliva and serum alkaloid concentrations. The possibility of using saliva as a biological matrix to detect DMT, β-carbolines, and their derivatives is very interesting because it allows fast noninvasive sample collection and could be useful for detecting similar alkaloids used recreationally that have considerable potential for intoxication
Subject: Ayahuasca
Country: Reino Unido
Editor: John Wiley & Sons
Rights: Fechado
Identifier DOI: 10.1002/dta.2955
Address: https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/dta.2955
Date Issue: 2021
Appears in Collections:FCM - Artigos e Outros Documentos
FCF - Artigos e Outros Documentos

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