Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/361834
Type: Artigo
Title: Dispersion of chitosan in liquid crystalline lamellar phase: Production of biofriendly hydrogel of nano cubic topology
Author: Mathews, Patrick D
Mertins, Omar
Abstract: Bicontinuous cubic phases were produced with introduction of chitosan in phospholipid/water hydro gel, providing composites of defined molecular organization. The ratio of lipid/water was constant and swelling of lipids bilayer is delimited by incorporation of polymer molecules into the structure. By means of synchrotron small angle X-ray scattering we identified topologies of coexisting cubic phases. The expected liquid crystalline L-alpha, lamellar phase was suppressed by 0.2 wt% chitosan leading to formation of diamond Pn3m and gyroid la3d cubic topology, with close lattice distances. An increment to 0.4 wt% chitosan caused large increase in Pn3m lattice distance. However a higher 0.6 wt% evolved this phase to a newly acquired primitive Im3m topology. The structuring process of the three-dimensional complex network is principally governed by demands of chitosan physical requirements over lipids bilayers interfacial curvature. The composite hydrogel of specific topologies presents reduced time release of gallic acid and may find application as new material for time-sustained delivery of bioactive compounds
Subject: Biomembranas
Country: Reino Unido
Editor: Elsevier
Rights: Fechado
Identifier DOI: 10.1016/j.carbpol.2016.10.071
Address: https://www.sciencedirect.com/science/article/pii/S0144861716312413
Date Issue: 2017
Appears in Collections:IB - Artigos e Outros Documentos

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.