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|Title:||Prevalence of potential drug-drug interactions in the intensive care unit of a Brazilian teaching hospital|
|Author:||Rodrigues, Aline Teotonio|
Eiras Falcao, Antonio Luis
Mazzola, Priscila Gava
|Abstract:||Patients in intensive care unit are prescribed large numbers of drugs, highlighting the need to study potential Drug-Drug Interactions in this environment. The aim of this study was to delineate the prevalence and risk of potential drug-drug interactions between medications administered to patients in an ICU. This cross-sectional observational study was conducted during 12 months, in an adult ICU of a teaching hospital. Inclusion criteria were: prescriptions with 2 or more drugs of patients admitted to the ICU for > 24 hours and age of >= 18 years. Potential Drug-Drug Interactions were quantified and classified through Micromedex (TM) database. The 369 prescriptions included in this study had 205 different drugs, with an average of 13.04 +/- 4.26 ( mean +/- standard deviation) drugs per prescription. Potential Drug-Drug Interactions were identified in 89% of these, with an average of 5.00 +/- 5.06 interactions per prescription. Of the 405 different pairs of potentially interacting drugs identified, moderate and major interactions were present in 74% and 67% of prescriptions, respectively. The most prevalent interaction was between dipyrone and enoxaparin (35.8%), though its clinical occurrence was not observed in this study. The number of potential Drug-Drug Interactions showed significant positive correlations with the length of stay in the intensive care unit, and with the number of prescribed drugs. Acknowledging the high potential for Drug-Drug Interactions in the ICU represents an important step toward improving patient safety and best therapy results|
|Subject:||Segurança do paciente|
|Editor:||USP/Faculdade de Ciências Farmacêuticas|
|Appears in Collections:||FCM - Artigos e Outros Documentos|
HEMO - Artigos e Outros Documentos
FCF - Artigos e Outros Documentos
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