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Type: Artigo
Title: TLR4-Mediated placental pathology and pregnancy outcome in experimental Malaria
Author: Barboza, Renato
Lima, Flavia Afonso
Reis, Aramys Silva
Murillo, Oscar Javier
Machado Peixoto, Erika Paula
Bandeira, Carla Leticia
Fotoran, Wesley Luzetti
Sardinha, Luis Roberto
Wunderlich, Gerhard
Bevilacqua, Estela
D'Imperio Lima, Maria Regina
Alvarez, Jose Maria
Maranhao Costa, Fabio Trindade
Goncalves, Ligia Antunes
Epiphanio, Sabrina
Farias Marinho, Cludio Romerso
Abstract: Malaria-associate pregnancy has a significant impact on infant morbidity and mortality. The detrimental effects of malaria infection during pregnancy have been shown to correlate with immune activation in the placental tissue. Herein we sought to evaluate the effect of Toll-like receptors (TLRs) activation on placental malaria (PM) development by using the Plasmodium berghei NK65(GFP) infection model. We observed that activation of the innate immune system by parasites leads to PM due to local inflammation. We identified TLR4 activation as the main pathway involved in the inflammatory process in the placental tissue since the absence of functional TLR4 in mice leads to a decrease in the pro-inflammatory responses, which resulted in an improved pregnancy outcome. Additionally, a similar result was obtained when infected pregnant mice were treated with IAXO-101, a TLR4/CD14 blocker. Together, this study illustrates the importance of TLR4 signalling for the generation of the severe inflammatory response involved in PM pathogenesis. Therefore, our results implicate that TLR4 blockage could be a potential candidate for therapeutic interventions to reduce malaria-induced pathology both in the mother and the fetus
Subject: Fator de necrose tumoral alfa
Imunidade natural
Country: Reino Unido
Editor: Springer Nature
Rights: Aberto
Identifier DOI: 10.1038/s41598-017-08299-x
Date Issue: 2017
Appears in Collections:IB - Artigos e Outros Documentos

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