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Type: Artigo
Title: snoRNA and piRNA expression levels modified by tobacco use in women with lung adenocarcinoma
Author: Nogueira Jorge, Natasha Andressa
Wajnberg, Gabriel
Ferreira, Carlos Gil
Carvalho, Benilton de Sa
Passetti, Fabio
Abstract: Lung cancer is one of the most frequent types of cancer worldwide. Most patients are diagnosed at advanced stage and thus have poor prognosis. Smoking is a risk factor for lung cancer, however most smokers do not develop lung cancer while 20% of women with lung adenocarcinoma are non-smokers. Therefore, it is possible that these two groups present differences besides the smoking status, including differences in their gene expression signature. The altered expression patterns of non-coding RNAs in complex diseases make them potential biomarkers for diagnosis and treatment. We analyzed data from differentially and constitutively expressed PIWI-interacting RNAs and small nucleolar RNAs from publicly available small RNA high-throughput sequencing data in search of an expression pattern of non-coding RNA that could differentiate these two groups. Here, we report two sets of differentially expressed small non-coding RNAs identified in normal and tumoral tissues of women with lung adenocarcinoma, that discriminate between smokers and non-smokers. Our findings may offer new insights on metabolic alterations caused by tobacco and may be used for early diagnosis of lung cancer
Subject: Células cancerosas
Country: Estados Unidos
Editor: Public Library of Science
Rights: Fechado
Identifier DOI: 10.1371/journal.pone.0183410
Date Issue: 2017
Appears in Collections:IMECC - Artigos e Outros Documentos

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