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|Title:||Aza-morita–baylis–hillman reaction with vinyl-oxadiazoles: an expeditious approach to access new heterocyclic arrangements|
Fernandes, Fábio S.
Rodrigues, Manoel T. Jr.
|Abstract:||In this communication, we disclosed a new aza-MBH reaction in which traditional nucleophilic partners of these reactions (e.g., acrylates, nitroolefins or enones) were replaced by vinyl-1,2,4-oxadiazoles. Thus, the aza-MBH reaction between 5-aryl-3-vinyl-1,2,4-oxadiazoles and N-sulfonylimines, catalyzed by the mixture DABCO/AcOH, provides a class of new adduct in yields varying from 31% up to 93% in reaction times from 30 minutes to 24 hours. Due to the biological activities and technological applications associated with the 1,2,4-oxadiazole motifs, this new class of heterocycles offers great synthetic and commercial potentiality|
|Editor:||Georg Thieme Verlag|
|Appears in Collections:||IQ - Artigos e Outros Documentos|
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