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Type: Artigo
Title: Aza-morita–baylis–hillman reaction with vinyl-oxadiazoles: an expeditious approach to access new heterocyclic arrangements
Author: Capretz-Agy, André
Fernandes, Fábio S.
Rodrigues, Manoel T. Jr.
Conti, Caroline
Coelho, Fernando
Abstract: In this communication, we disclosed a new aza-MBH reaction in which traditional nucleophilic partners of these reactions (e.g., acrylates, nitroolefins or enones) were replaced by vinyl-1,2,4-oxadiazoles. Thus, the aza-MBH reaction between 5-aryl-3-vinyl-1,2,4-oxadiazoles and N-sulfonylimines, catalyzed by the mixture DABCO/AcOH, provides a class of new adduct in yields varying from 31% up to 93% in reaction times from 30 minutes to 24 hours. Due to the biological activities and technological applications associated with the 1,2,4-oxadiazole motifs, this new class of heterocycles offers great synthetic and commercial potentiality
Subject: N-heterociclos
Country: Alemanha
Editor: Georg Thieme Verlag
Rights: Fechado
Identifier DOI: 10.1055/s-0039-1691497
Date Issue: 2020
Appears in Collections:IQ - Artigos e Outros Documentos

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