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|Title:||Characterization of the antioxidant activity of aglycone and glycosylated derivatives of hesperetin: an in vitro and in vivo study|
|Author:||de Souza, Veronica Tricoli|
Dini de Franco, Elida Paula
Melo Branco de Araujo, Maria Elisa
Fernandes Messias, Marcia Cristina
Marinho Priviero, Fernanda Bruschi
Frankland Sawaya, Alexandra C. H.
Carvalho, Patricia de Oliveira
|Abstract:||The flavonoids are mainly present in Citrus fruits as their glycosyl derivatives. This study was conducted comparing in vitro xanthine oxidase inhibitory activity of the aglycone hesperetin and its glycosylated forms (hesperidin and G-hesperidin) and their effects on the plasma lipid profile and the oxidative-antioxidative system (TBARS and antioxidant enzymes) in rats. The concentrations of the major conjugated metabolites in rat plasma after oral administration of these compounds were also determined. Wistar male rats were randomly assigned to three groups (n = 6) supplemented for 30 days with 1 mmol/kg body mass of hesperetin, hesperidin or G-hesperidin. Hesperetin was a stronger xanthine oxidase inhibitor (IC50=53 mu M and K-i = 17.3 mu M) than the glycosylate derivatives. Supplementation with the three compounds led to a lower (more favorable) atherogenic index, and an antioxidant preventive effect from the increase of hepatic superoxide dismutase was observed associated to HT supplementation, possibly because of the higher level of hesperetin-glucuronide in rat plasma|
|Appears in Collections:||FCF - Artigos e Outros Documentos|
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