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|Title:||The expression of the androgen receptor and Estrogen Receptor 1 is related to sex dimorphism in the gerbil prostate development|
|Author:||Sanches, Bruno D. A.|
Maldarine, Juliana S.
Zani, Bruno C.
Biancardi, Manoel F.
Santos, Fernanda C. A.
Goes, Rejane M.
Vilamaior, Patricia S. L.
Taboga, Sebastiao R.
|Abstract:||The development of the prostate gland in females has not yet been clearly elucidated, and the sexual dimorphism associated with such gland development in general is far from being understood. In the present study, we used tridimensional (3D) reconstructions and histochemical and immunohistochemical techniques to describe the sexual dimorphism and its causes in the early postnatal development of the prostate in male and female Mongolian gerbils (Meriones unguiculatus). We observed that the female prostate was smaller, had fewer branches throughout the development, and underwent differentiation earlier than that in males. Also, the expression of the estrogen receptor 1 (ESR1 or ER-alpha) and fibroblast growth factor 10 (FGF10) was decreased in the periductal region, and the expression of the androgen receptor (AR) was increased in the epithelium. All together, these changes decreased proliferation and branching and led to an earlier prematuration of the female prostate. These new data shed light on the underlying mechanisms involved with the sexual dimorphism in the development of the prostate. Anat Rec, 299:1130-1139, 2016|
Sexo - Diferenças
|Editor:||John Wiley & Sons|
|Appears in Collections:||IB - Artigos e Outros Documentos|
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