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Type: Artigo
Title: Aligned biomimetic scaffolds based on carbon nanotubes-reinforced polymeric nanofibers for knee meniscus tissue engineering
Author: Stocco, Thiago D.
Antonioli, Eliane
Romagnolli, Maria L.
Sousa, Gustavo F.
Ferretti, Mario
Lobo, Anderson O.
Abstract: Many strategies in tissue engineering have been developed in order to provide potential treatments for Knee meniscal injuries since it is a high incidence lesion and without effective treatment available in clinical practice. The success of this approach is directly related to the creation of a scaffold able to reproduce the complex extracellular matrix of the native meniscus with adequate mechanical properties. Here we fabricated an aligned biomimetic scaffold, based on carbon nanotube (CNT)-reinforced polymeric nanofibers. For that, scaffolds with both circumferentially and radially aligned polycaprolactone fibers were developed from a specific electrospinning setup and incorporated with two different concentrations of CNT: 0.05% and 0.10%. Characterization by scanning electron microscopy confirmed the spatial distribution and the alignment of the electrospun nanofibers as well as a decrease in average fiber size with the addition of CNT (the presence of CNT was confirmed by transmission electron microscopy). Dynamic mechanical analysis and biological assays showed an improvement in the mechanical properties related to increased CNT content without influence in mesenchymal stem cells survival. These findings suggest a potential applicability of this nanocomposite for knee meniscus tissue engineering
Subject: Nanotubos de carbono
Nanocompósitos (Materiais)
Country: Países Baixos
Editor: Elsevier
Rights: Fechado
Identifier DOI: 10.1016/j.matlet.2020.127351
Date Issue: 2020
Appears in Collections:FCM - Artigos e Outros Documentos

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