Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/357365
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampSanches, Bruno Domingos Azevedo-
dc.contributor.authorunicampBiancardi, Manoel Francisco-
dc.contributor.authorunicampAntoniassi, Julia Quilles-
dc.typeArtigopt_BR
dc.titleIntrauterine exposure to oestradiol promotes sex‐specific differential effects on the prostatic development of neonate gerbilspt_BR
dc.contributor.authorSanches, Bruno D. A.-
dc.contributor.authorMaldarine, Juliana S.-
dc.contributor.authorBiancardi, Manoel F.-
dc.contributor.authorSantos, Fernanda C. A.-
dc.contributor.authorPinto‐Fochi, Maria E.-
dc.contributor.authorAntoniassi, Julia Q.-
dc.contributor.authorGóes, Rejane M.-
dc.contributor.authorVilamaior, Patrícia S. L.-
dc.contributor.authorTaboga, Sebastião R.-
dc.subjectPróstata femininapt_BR
dc.subject.otherlanguageFemale prostatept_BR
dc.description.abstractThe effects of intrauterine exposure to 17β‐oestradiol (E2) are well studied for the male prostate and there are accumulating evidences that the exposure to high dosages leads to a hypomorphic development. However, there is a lack of information about the effects of intrauterine exposure to E2 in the prostate of rodent females, and such research becomes relevant in view of the presence of functional prostate in a proportion of women, and the morphophysiological similarities between the prostate of female rodents and the prostate of women. This study uses histochemical, immunohistochemical, immunofluorescence and three‐dimensional (3D) reconstruction techniques to evaluate the effects of intrauterine exposure to E2 (500 BW/d) on neonatal prostate development in both male and female gerbils. It was verified that intrauterine exposure to E2 promotes epithelial proliferation and growth of prostatic budding in females, whereas in males the prostatic budding shows hypomorphic growth in the VMP (Ventral Mesenchymal Pad) as well as reduced epithelial proliferation. Together, the data demonstrate that intrauterine exposure to E2 causes different effects on male and female prostates of the gerbil even at the early postnatal development of the glanpt_BR
dc.relation.ispartofCell biology internationalpt_BR
dc.relation.ispartofabbreviationCell biol. int.pt_BR
dc.publisher.cityOxfordpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherJohn Wiley & Sonspt_BR
dc.date.issued2017-
dc.date.monthofcirculationNov.pt_BR
dc.language.isoengpt_BR
dc.description.volume41pt_BR
dc.description.issuenumber11pt_BR
dc.description.firstpage1184pt_BR
dc.description.lastpage1193pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn1065-6995pt_BR
dc.identifier.eissn1095-8355pt_BR
dc.identifier.doi10.1002/cbin.10829pt_BR
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/full/10.1002/cbin.10829pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumber442630/2014-0pt_BR
dc.description.sponsordocumentnumber2013/159390; 2013/16443-9; 2013/15939-0; 2013/16443-9pt_BR
dc.date.available2021-03-09T18:06:55Z-
dc.date.accessioned2021-03-09T18:06:55Z-
dc.description.provenanceSubmitted by Thais de Brito Barroso (tbrito@unicamp.br) on 2021-03-09T18:06:55Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-09-02T14:25:59Z : No. of bitstreams: 1 000416618000003.pdf: 2012958 bytes, checksum: c8d048f39e25f34c915c34e4521b92db (MD5)en
dc.description.provenanceMade available in DSpace on 2021-03-09T18:06:55Z (GMT). No. of bitstreams: 0 Previous issue date: 2017en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/357365-
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.subject.keywordFGF-10pt_BR
dc.subject.keywordOestradiolpt_BR
dc.subject.keywordProstate developmentpt_BR
dc.subject.keywordSex differencespt_BR
dc.subject.keywordTGF beta 2pt_BR
dc.identifier.source000416618000003pt_BR
dc.creator.orcid0000-0002-2139-5991pt_BR
dc.creator.orcid0000-0001-9995-3546pt_BR
dc.creator.orcid0000-0002-4015-371Xpt_BR
dc.type.formArtigo de pesquisapt_BR
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