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dc.contributor.authorunicampPerson, Rosangela Duarte de Medeiros-
dc.contributor.authorunicampCastilho, Lilian Maria de-
dc.titleRHCE variants inherited with altered RHD alleles in brazilian blood donorspt_BR
dc.contributor.authorPrisco Arnoni, C.-
dc.contributor.authorGuilhem Muniz, J.-
dc.contributor.authorde Paula Vendrame, T. A.-
dc.contributor.authorde Medeiros Person, R.-
dc.contributor.authorRoche Moreira Latini, F.-
dc.contributor.authorCastilho, L.-
dc.subjectVariantes RHCEpt_BR
dc.subjectSistema do grupo sanguíneo Rh-Hrpt_BR
dc.subject.otherlanguageRh-Hr blood-group systempt_BR
dc.subject.otherlanguageRHCE variantspt_BR
dc.description.abstractThe high homology and opposite orientation of RH genes promote rearrangements between them and generate a large number of RHD and RHCE variants which can be inherited together. Searching of RHD-CE genotypes predicting partial antigens in donors is of interest in order to find more closely matched donors for African descent patients. This study aimed to evaluate a molecular approach to search for RhCE variants in a cohort of individuals with altered expression of D antigen and determine the association of RH variant alleles in Brazilian blood donors. From 80,961 blood samples tested, 421 with atypical D typing results were studied. The samples were phenotyped for C, c, E, e antigens. Rh variants were identified using molecular techniques. All 421 samples had altered RHD alleles, being 563% of them partial D. Among them, 949% presented variant RHCE*ce and the most common associations were: RHD*weak D type 4.2.2 with RHCE*ceAR; RHD*DAR linked to RHCE*ceVS.02; RHD*weak D type 4.0 linked to RHCE*ceVS.02 and RHCE*ce (c.48C, c.105T, c.733G, c.744C, c.1025T). Among the samples with RhCE variants, 106% predict partial c, partial e, hr(B)- and/or hr(S)- and 100% express low prevalence antigens. Targeting individuals with altered expression of D antigen can be a good strategy for finding donors with RhCE variants. In our study 949% of the partial D samples revealed altered RHCE variant alleles and 57% of the samples with altered RHD allele predicted partial c, partial e and the lack of the high prevalence hr(B)and hr(S)antigenspt_BR
dc.relation.ispartofTransfusion medicinept_BR
dc.relation.ispartofabbreviationTransfus. med.pt_BR
dc.publisher.countryReino Unidopt_BR
dc.description.provenanceSubmitted by Cintia Oliveira de Moura ( on 2021-02-27T15:58:38Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-05-25T14:37:59Z : No. of bitstreams: 1 000384665900006.pdf: 247386 bytes, checksum: a6af86c9c5ed421f2fd9dce0467ae431 (MD5)en
dc.description.provenanceMade available in DSpace on 2021-02-27T15:58:38Z (GMT). No. of bitstreams: 0 Previous issue date: 2016en
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeCentro de Hematologia e Hemoterapiapt_BR
dc.creator.orcidsem informaçãopt_BR
dc.type.formArtigo originalpt_BR
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