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Type: Artigo
Title: Deracemization of 1-phenylethanol via tandem biocatalytic oxidation and reduction
Author: Nasario, Fabio D.
Cazetta, Tarcila
Moran, Paulo J. S.
Rodrigues, J. Augusto R.
Abstract: (R)-1-Arylethanols and other secondary alcohols were prepared at high ee (>90%) by oxidative kinetic resolution using resting cells of the yeast Candida albicans CCT 0776. The deracemization process of 1-phenylethanol la catalyzed by the yeast was elucidated by studying each step separately. It was determined that the reaction occurred via cyclic deracemization, to give (R)-1a in 89% yield and with 98% ee. Finally, deracemization by stereoinversion of rac-1a was studied using a tandem process of C. albicans followed by Lactobacillus brevis CCT 3745. Inverting the sequence of these microorganisms produced an enantiomerically pure antipode
Subject: Estereoinversão
Country: Reino Unido
Editor: Elsevier
Rights: Fechado
Identifier DOI: 10.1016/j.tetasy.2016.03.008
Date Issue: 2016
Appears in Collections:IQ - Artigos e Outros Documentos

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