Please use this identifier to cite or link to this item:
|Title:||Deracemization of 1-phenylethanol via tandem biocatalytic oxidation and reduction|
|Author:||Nasario, Fabio D.|
Moran, Paulo J. S.
Rodrigues, J. Augusto R.
|Abstract:||(R)-1-Arylethanols and other secondary alcohols were prepared at high ee (>90%) by oxidative kinetic resolution using resting cells of the yeast Candida albicans CCT 0776. The deracemization process of 1-phenylethanol la catalyzed by the yeast was elucidated by studying each step separately. It was determined that the reaction occurred via cyclic deracemization, to give (R)-1a in 89% yield and with 98% ee. Finally, deracemization by stereoinversion of rac-1a was studied using a tandem process of C. albicans followed by Lactobacillus brevis CCT 3745. Inverting the sequence of these microorganisms produced an enantiomerically pure antipode|
|Appears in Collections:||IQ - Artigos e Outros Documentos|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.