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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampCintra, Dennys Esper-
dc.typeArtigopt_BR
dc.titleDietary interesterified fat enriched with palmitic acid induces atherosclerosis by impairing macrophage cholesterol efflux and eliciting inflammationpt_BR
dc.contributor.authorAfonso, Milessa Silva-
dc.contributor.authorFerrari Lavrador, Maria Silvia-
dc.contributor.authorKoike, Marcia Kiyomi-
dc.contributor.authorCintra, Dennys Esper-
dc.contributor.authorFerreira, Fabiana Dias-
dc.subjectAterosclerosept_BR
dc.subjectLipoproteínaspt_BR
dc.subject.otherlanguageAtherosclerosispt_BR
dc.subject.otherlanguageLipoproteinspt_BR
dc.description.abstractInteresterified fats are currently being used to replace trans fatty acids. However, their impact on biological pathways involved in the atherosclerosis development was not investigated. Weaning male LDLr-KO mice were fed for 16 weeks on a high-fat diet (40% energy as fat) containing polyunsaturated (PUFA), TRANS, palmitic (PALM), palmitic interesterified (PALM INTER), stearic (STEAR) or stearic interesterified (STEAR INTER). Plasma lipids, lipoprotein profile, arterial lesion area, macrophage infiltration, collagen content and inflammatory response modulation were determined. Macrophage cholesterol efflux and the arterial expression of cholesterol uptake and efflux receptors were also performed. The interesterification process did not alter plasma lipid concentrations. Although PALM INTER did not increase plasma cholesterol concentration as much as TRANS, the cholesterol enrichment in the LDL particle was similar in both groups. Moreover, PALM INTER induced the highest IL-1 beta, MCP-1 and IL-6 secretion from peritoneal macrophages as compared to others. This inflammatory response elicited by PALM INTER was confirmed in arterial wall, as compared to PALM. These deleterious effects of PALM INTER culminate in higher atherosclerotic lesion, macrophage infiltration and collagen content than PALM, STEAR, STEAR INTER and PUFA. These events can partially be attributed to a macrophage cholesterol accumulation, promoted by apoAl and HDL2-mediated cholesterol efflux impairment and increased Olr-1 and decreased Abca1 and Nr1h3 expressions in the arterial wall. Interesterified fats containing palmitic acid induce atherosclerosis development by promoting cholesterol accumulation in LDL particles and macrophagic cells, activating the inflammatory process in LDLr-KO micept_BR
dc.relation.ispartofThe journal of nutritional biochemistrypt_BR
dc.relation.ispartofabbreviationJ nutr biochempt_BR
dc.publisher.cityNew York, NYpt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherElsevierpt_BR
dc.date.issued2016-
dc.date.monthofcirculationJunept_BR
dc.language.isoengpt_BR
dc.description.volume32pt_BR
dc.description.firstpage91pt_BR
dc.description.lastpage100pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0955-2863pt_BR
dc.identifier.eissn1873-4847pt_BR
dc.identifier.doi10.1016/j.jnutbio.2016.01.005pt_BR
dc.identifier.doi10.1016/j.jnutbio.2016.08.001pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S095528631600036Xpt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0955286316303369pt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumber11/50443-0; 12/50249-2pt_BR
dc.date.available2021-02-26T19:39:43Z-
dc.date.accessioned2021-02-26T19:39:43Z-
dc.description.provenanceSubmitted by Cintia Oliveira de Moura (cintiaom@unicamp.br) on 2021-02-26T19:39:43Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-05-25T14:37:56Z : No. of bitstreams: 1 000377634300010.pdf: 1611798 bytes, checksum: d147cd08e4273be3037000de8e1c0e80 (MD5). Added 1 bitstream(s) on 2021-05-25T14:37:56Z : No. of bitstreams: 2 000377634300010.pdf: 1611798 bytes, checksum: d147cd08e4273be3037000de8e1c0e80 (MD5) 000385213000009_Errata.pdf: 192539 bytes, checksum: ffa25d0cd464c3357887fa133cbea2ee (MD5)en
dc.description.provenanceMade available in DSpace on 2021-02-26T19:39:43Z (GMT). No. of bitstreams: 0 Previous issue date: 2016en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/356643-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.unidadeFaculdade de Ciências Aplicadaspt_BR
dc.identifier.source000377634300010pt_BR
dc.identifier.source000385213000009pt_BR
dc.creator.orcid0000-0002-7954-5630pt_BR
dc.type.formArtigo de pesquisapt_BR
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