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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampDragano, Nathalia Romanelli Vicente-
dc.contributor.authorunicampGarcia, Albina de Fátima Silva Ramalho-
dc.contributor.authorunicampVitorino, Daniele Cristina-
dc.contributor.authorunicampLima, Maria Helena de Melo-
dc.contributor.authorunicampVelloso, Licio Augusto-
dc.contributor.authorunicampAraujo, Eliana Pereira de-
dc.typeArtigopt_BR
dc.titleTopical docosahexaenoic acid (DHA) accelerates skin wound healing in rats and activates GPR120pt_BR
dc.contributor.authorArantes, Eva L.-
dc.contributor.authorDragano, Nathalia-
dc.contributor.authorRamalho, Albina-
dc.contributor.authorVitorino, Daniele-
dc.contributor.authorde-Souza, Gabriela F.-
dc.contributor.authorLima, Maria H. M.-
dc.contributor.authorVelloso, Licio A.-
dc.contributor.authorAraújo, Eliana P.-
dc.subjectÁcidos graxos insaturadospt_BR
dc.subject.otherlanguageUnsaturated fatty acidspt_BR
dc.description.abstractThe development of methods for improving skin wound healing may have an impact on the outcomes of a number of medical conditions. The topical use of polyunsaturated fatty acids (PUFAs) can accelerate skin wound healing through mechanisms that involve, at least in part, the modulation of inflammatory activity. Purpose: We evaluated whether G-protein-coupled receptor 120 (GPR120), a recently identified receptor for docosahexaenoic acid (DHA) with anti-inflammatory activity, is expressed in the skin and responds to topical DHA. Method: Male Wistar rats were submitted to an 8.0-mm wound on the back and were immediately administered a topical treatment of a solution containing 30 μM of DHA once a day. The healing process was photodocumented, and tissues were collected on Days 5, 9, and 15 for protein and RNA analyses and histological evaluation. Results: GPR120 was expressed in the intact skin and in the wound. Keratinocytes expressed the most skin GPR120, while virtually no expression was detected in fibroblasts. Upon DHA topical treatment, wound healing was significantly accelerated and was accompanied by the molecular activation of GPR120, as determined by its association with β-arrestin-2. In addition, DHA promoted a reduction in the expression of interleukin (IL) 1β and an increase in the expression of IL-6. Furthermore, there was a significant increase in expression of transforming growth factor β (TGF-β) and the keratinocyte marker involucrin. Discussion: Topical DHA improved skin wound healing. The activation of GPR120 is potentially involved in this processpt_BR
dc.relation.ispartofBiological research for nursing: integrating biobehavioral research into health carept_BR
dc.relation.ispartofabbreviationBiol. res. nurs.pt_BR
dc.publisher.cityThousand Oaks, CApt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherSagept_BR
dc.date.issued2016-
dc.date.monthofcirculationJulypt_BR
dc.language.isoengpt_BR
dc.description.volume18pt_BR
dc.description.issuenumber4pt_BR
dc.description.firstpage411pt_BR
dc.description.lastpage419pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn1099-8004pt_BR
dc.identifier.eissn1552-4175pt_BR
dc.identifier.doi10.1177/1099800415621617pt_BR
dc.identifier.urlhttps://journals.sagepub.com/doi/10.1177/1099800415621617pt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumberSem informaçãopt_BR
dc.date.available2021-02-26T15:32:35Z-
dc.date.accessioned2021-02-26T15:32:35Z-
dc.description.provenanceSubmitted by Thais de Brito Barroso (tbrito@unicamp.br) on 2021-02-26T15:32:35Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-05-24T16:47:37Z : No. of bitstreams: 1 000378747300006.pdf: 2198081 bytes, checksum: ea88bc2aba2611472f9553451c3f07ea (MD5)en
dc.description.provenanceMade available in DSpace on 2021-02-26T15:32:35Z (GMT). No. of bitstreams: 0 Previous issue date: 2016en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/356554-
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentDepartamento de Clínica Médicapt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Enfermagempt_BR
dc.subject.keywordGPR120pt_BR
dc.subject.keywordInflammationpt_BR
dc.subject.keywordTGF-βpt_BR
dc.identifier.source000378747300006pt_BR
dc.creator.orcid0000-0002-6856-5468pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcid0000-0001-6521-8324pt_BR
dc.creator.orcid0000-0002-4806-7218pt_BR
dc.creator.orcid0000-0002-7539-8477pt_BR
dc.type.formArtigopt_BR
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