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|Title:||A strategy for the rapid identification of fungal metabolites and the discovery of the antiviral activity of pyrenocine a and harzianopyridon|
|Author:||Ióca, Laura P.|
Santos, Mario F. C.
Bandeira, Karin F.
Rodrigues, Fabiana T.
Kossuga, Miriam H.
Nicacio, Karen J.
Ferreira, Everton L. F.
Morais-Urano, Raquel P.
Passos, Messias S.
Kohn, Luciana K.
Arns, Clarice W.
Sette, Lara D.
Berlinck, Roberto G. S.
|Abstract:||The isolation and identification of bioactive metabolites from complex extracts obtained from microbial growth media is a time consuming, costly, and labor-intensive task. A strategy to rapidly identify secondary metabolites isolated from extracts obtained from the culture media of marine-derived and endophytic fungal strains is described. Identification was achieved by HPLC-UV-MS and 1H NMR analyses in combination with data obtained from the Dictionary of Natural Products. Among the compounds identified, (-)-naphthoquinoneimine, citreorosein, emodin, pyrenocine A and harzianopyridone displayed moderate to potent antiviral activity. (-)-Naphthoquinoneimine was isolated as the enantiomer of its previously reported dextrorotatory congener, while 6,7-dihydroxy-2,2-dimethyl-4-chromanone is herein reported for the first time as a natural product|
|Editor:||Sociedade Brasileira de Química|
|Appears in Collections:||IB - Artigos e Outros Documentos|
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