Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/356461
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampReichert Lima, Franqueline-
dc.contributor.authorunicampPeron, Isabela Haddad-
dc.contributor.authorunicampMoretti, Maria Luiza-
dc.contributor.authorunicampSchreiber, Angélica Zaninelli-
dc.typeArtigopt_BR
dc.titleEvaluation of antifungal combination against Cryptococcus spppt_BR
dc.contributor.authorReichert-Lima, Franqueline-
dc.contributor.authorBusso-Lopes, Ariane F.-
dc.contributor.authorLyra, Luzia-
dc.contributor.authorPeron, Isabela Haddad-
dc.contributor.authorTaguchi, Hideaki-
dc.contributor.authorMikami, Yuzuru-
dc.contributor.authorKamei, Katsuiko-
dc.contributor.authorMoretti, Maria Luiza-
dc.contributor.authorSchreiber, Angelica Z.-
dc.subjectCryptococcuspt_BR
dc.subjectAntifúngicospt_BR
dc.subject.otherlanguageCryptococcuspt_BR
dc.subject.otherlanguageAntifungal agentspt_BR
dc.description.abstractThe second cause of death among systemic mycoses, cryptococcosis treatment represents a challenge since that 5-flucytosine is not currently available in Brazil. Looking for alternatives, this study evaluated antifungal agents, alone and combined, correlating susceptibility to genotypes. Eighty Cryptococcus clinical isolates were genotyped by URA5 gene restriction fragment length polymorphism. Antifungal susceptibility was assessed following CLSI-M27A3 for amphotericin (AMB), 5-flucytosine (5FC), fluconazole (FCZ), voriconazole (VRZ), itraconazole (ITZ) and terbinafine (TRB). Drug interaction chequerboard assay evaluated: AMB + 5FC, AMB + FCZ, AMB + TRB and FCZ + TRB. Molecular typing divided isolates into 14 C. deuterogattii (VGII) and C. neoformans isolates were found to belong to genotype VNI (n = 62) and VNII (n = 4). C. neoformans VNII was significantly less susceptible than VNI (P = 0.0407) to AMB; C. deuterogattii was significantly less susceptible than VNI and VNII to VRZ (P < 0.0001). C. deuterogattii was less susceptible than C. neoformans VNI for FCZ (P = 0.0170), ITZ (P < 0.0001) and TRB (P = 0.0090). The combination FCZ + TRB showed 95.16% of synergistic effect against C. neoformans genotype VNI isolates and all combinations showed 100% of synergism against genotype VNII isolates, suggesting the relevance of cryptococcal genotyping as it is widely known that the various genotypes (now species) have significant impact in antifungal susceptibilities and clinical outcome. In difficult-to-treat cryptococcosis, terbinafine and different antifungal combinations might be alternatives to 5FCpt_BR
dc.relation.ispartofMycoses: diagnosis, therapy and prophylaxis of fungal diseasespt_BR
dc.relation.ispartofabbreviationMycosespt_BR
dc.publisher.cityChichesterpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherWileypt_BR
dc.date.issued2016-
dc.date.monthofcirculationSep.pt_BR
dc.language.isoengpt_BR
dc.description.volume59pt_BR
dc.description.issuenumber9pt_BR
dc.description.firstpage585pt_BR
dc.description.lastpage593pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0933-7407pt_BR
dc.identifier.eissn1439-0507pt_BR
dc.identifier.doi10.1111/myc.12510pt_BR
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/full/10.1111/myc.12510pt_BR
dc.date.available2021-02-25T14:31:44Z-
dc.date.accessioned2021-02-25T14:31:44Z-
dc.description.provenanceSubmitted by Cintia Oliveira de Moura (cintiaom@unicamp.br) on 2021-02-25T14:31:44Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-05-25T14:37:51Z : No. of bitstreams: 1 000383256700006.pdf: 212971 bytes, checksum: d3f4950d9affe6d2c92390d4b437393e (MD5)en
dc.description.provenanceMade available in DSpace on 2021-02-25T14:31:44Z (GMT). No. of bitstreams: 0 Previous issue date: 2016en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/356461-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Clínica Médicapt_BR
dc.contributor.departmentDepartamento de Patologia Clínicapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.identifier.source000383256700006pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0003-4760-0540pt_BR
dc.creator.orcid0000-0002-2280-5649pt_BR
dc.creator.orcid0000-0002-5095-5054pt_BR
dc.type.formArtigo originalpt_BR
dc.description.sponsorNoteJICA (Japan International Cooperation Agency); SATREPS (Science and Technology Research Partnership for Sustainable Development)pt_BR
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