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|Title:||Contemporary human papillomavirus genotyping and correlations to peniscopy, cytology, and histopatology on over 1000 males|
|Author:||Truzzi, Jose Carlos|
Silva, Ismael Dale
Freire, Marcos Paulo
Neto, Miguel Jorge
Rodrigues, Fabio Ferro
Maciel, Gustavo Arantes
Reis, Leonardo O.
|Abstract:||To explore male human papillomavirus (HPV) contemporary genotyping epidemiology and correlations to peniscopy, cytology, and histopatology. Medical records of patients who had been submitted to HPV infection screening with genotyping, peniscopy, cytology, and histopathology in a period of 2 years were reviewed. Frequency analysis and correlations between the diagnostic tools were established. Genotype of 1132 men resulted in 69.2% (784) positivity for HPV DNA, 78% classified as high risk of oncogenesis. Co‐infections occurred in 429 (54.7%) and the most frequently identified types were HPV‐6, HPV‐42, and HPV‐16, in 133 (17%), 94 (12%), and 86 (11%) patients, respectively. Positive/negative predictive values of peniscopy, cytology, and histopathology were 83/31%, 92/32%, and 87/33%, respectively. As a result, though significant, the correlations between genotype and non‐molecular tests were poor. In the current contemporary representative male cohort, over two thirds are positive for human HPV DNA, 78% of high risk and with over half co‐infections. Though significant, its correlation with non‐molecular tests is poor and while the positive predictive values of peniscopy, cytology, and histopatology are between 83% and 92%, their negative predictive values are as low as 31% to 33%|
|Editor:||John Wiley & Sons|
|Appears in Collections:||FCM - Artigos e Outros Documentos|
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