Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/356314
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampBernedo-Navarro, Robert Alvin-
dc.contributor.authorunicampYano, Tomomasa-
dc.typeArtigopt_BR
dc.titlePhage display and Shiga toxin neutralizerspt_BR
dc.contributor.authorBernedo-Navarro, Robert Alvin-
dc.contributor.authorYano, Tomomasa-
dc.subjectEscherichia colipt_BR
dc.subject.otherlanguageEscherichia colipt_BR
dc.description.abstractThe current work presents an overview of the use of phage display technology for the identification and characterization of potential neutralizing agents for Shiga toxins. The last major Shiga toxin-associated disease outbreak, which took place in Germany in 2011, showed the international community that Shiga toxins remain a serious threat to public health. This is also demonstrated by the lack of specific therapies against Shiga toxin-induced Hemolytic Uremic Syndrome (HUS). Since its inception, phage display technology has played a key role in the development of antigen-specific (poly)-peptides or antibody fragments with specific biological properties. Herein, we review the current literature regarding the application of phage display to identify novel neutralizing agents against Shiga toxins. We also briefly highlight reported discoveries of peptides and heavy chain antibodies (VHH fragments or nanobodies) that can neutralize the cellular damage caused by these potent toxinspt_BR
dc.relation.ispartofToxicon: an interdisciplinary journal on the toxins derived from animals, plants and microorganismspt_BR
dc.relation.ispartofabbreviationToxiconpt_BR
dc.publisher.cityOxfordpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherElsevierpt_BR
dc.date.issued2016-
dc.date.monthofcirculationApr.pt_BR
dc.language.isoengpt_BR
dc.description.volume113pt_BR
dc.description.firstpage60pt_BR
dc.description.lastpage69pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0041-0101pt_BR
dc.identifier.eissn1879-3150pt_BR
dc.identifier.doi10.1016/j.toxicon.2016.02.009pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0041010116300277pt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumbersem informaçãopt_BR
dc.date.available2021-02-23T13:04:23Z-
dc.date.accessioned2021-02-23T13:04:23Z-
dc.description.provenanceSubmitted by Sanches Olivia (olivias@unicamp.br) on 2021-02-23T13:04:23Z No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2021-02-23T13:04:23Z (GMT). No. of bitstreams: 0 Previous issue date: 2016en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/356314-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Genética, Evolução e Bioagentespt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.subject.keywordSTECpt_BR
dc.subject.keywordShiga toxinspt_BR
dc.subject.keywordPhage displaypt_BR
dc.identifier.source000372937600010pt_BR
dc.creator.orcid0000-0002-8105-0418pt_BR
dc.creator.orcid0000-0002-1213-6453pt_BR
dc.type.formArtigo de revisãopt_BR
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