Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/356307
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampHetzl, Amanda Cia-
dc.contributor.authorunicampMontico, Fabio-
dc.contributor.authorunicampKido, Larissa Akemi-
dc.contributor.authorunicampCagnon, Valéria Helena Alves-
dc.typeArtigopt_BR
dc.titleProlactin, EGFR, vimentin and α-actin profiles in elderly rat prostate subjected to steroid hormonal imbalancept_BR
dc.contributor.authorHetzl, Amanda Cia-
dc.contributor.authorMontico, Fabio-
dc.contributor.authorKido, Larissa Akemi-
dc.contributor.authorAlves Cagnon, Valeria Helena-
dc.subjectProlactinapt_BR
dc.subject.otherlanguageProlactinpt_BR
dc.description.abstractThe aim of this study was to characterize and relate the prolactin (PR), epidermal growth factor receptor (EGFR), alpha-actin and vimentin immunoreactivity in the prostate of elderly rats subjected to steroid hormonal imbalance. Senile and young rats were divided into the young group (YNG), the senile group (SE), the castrated group (CAS), the estrogen-deficient group (ED), the castrated + estrogen group (CASE), and the estrogen-deficient + androgen group (EDTEST). PR and EGFR increased in the estrogen and androgen ablation groups. In addition, EGFR influenced the immunolocalization by changing it from the prostatic stroma to the epithelium in elderly rats. Hormone ablation in elderly rats, not only related to androgen but also estrogen, led to increased stromal EGFR immunolocalization. The alpha-actin pattern decreased in the groups with estrogenic imbalance. Moreover, vimentin increased in the senile and estrogen deficient group. To conclude, we can suggest that EGFR contributed towards the proliferative process in the prostate, by means however, of different mechanisms, considering the androgenic and estrogenic pathways. Also, our results indicated that prolactin could be activated not only in an androgen-independent pathway but also in an estrogen independent pathway. Finally, PR and vimentin immunolocalization increase, in the prostatic stroma in the group showing estrogenic ablation, could be one of the factors which contribute to the reactive stroma formationpt_BR
dc.relation.ispartofTissue and cellpt_BR
dc.publisher.cityOxfordpt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherElsevierpt_BR
dc.date.issued2016-
dc.date.monthofcirculationJunept_BR
dc.language.isoengpt_BR
dc.description.volume48pt_BR
dc.description.issuenumber3pt_BR
dc.description.firstpage189pt_BR
dc.description.lastpage196pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0040-8166pt_BR
dc.identifier.doi10.1016/j.tice.2016.03.008pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0040816615300124pt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumber2010/01739-1; 2009/50396-2pt_BR
dc.date.available2021-02-23T12:08:20Z-
dc.date.accessioned2021-02-23T12:08:20Z-
dc.description.provenanceSubmitted by Sanches Olivia (olivias@unicamp.br) on 2021-02-23T12:08:20Z No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2021-02-23T12:08:20Z (GMT). No. of bitstreams: 0 Previous issue date: 2016en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/356307-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Biologia Estrutural e Funcionalpt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.subject.keywordProstatept_BR
dc.subject.keywordRatpt_BR
dc.subject.keywordEgfrpt_BR
dc.subject.keywordVimentin and alpha-actinpt_BR
dc.identifier.source000376396200006pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0001-8360-0842pt_BR
dc.creator.orcid0000-0002-3653-8035pt_BR
dc.creator.orcid0000-0001-5331-7376pt_BR
dc.type.formArtigopt_BR
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