Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/356111
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampSilva, Marilene Neves da-
dc.contributor.authorunicampVieira-Damiani, Gislaine-
dc.contributor.authorunicampGilioli, Rovilson-
dc.contributor.authorunicampAlmeida, Amanda Roberta de-
dc.contributor.authorunicampDrummond, Marina Rovani-
dc.contributor.authorunicampLania, Bruno Grosselli-
dc.contributor.authorunicampLins, Karina de Almeida-
dc.contributor.authorunicampSoares, Tânia Cristina Benetti-
dc.contributor.authorunicampVelho, Paulo Eduardo Neves Ferreira-
dc.typeArtigopt_BR
dc.titleBartonella henselae transmission by blood transfusion in micept_BR
dc.contributor.authorSilva, Marilene Neves-
dc.contributor.authorVieira‐Damiani, Gislaine-
dc.contributor.authorEricson, Marna Elise-
dc.contributor.authorGilioli, Kalpna Gupta Rovilson-
dc.contributor.authorAlmeida, Amanda Roberta de-
dc.contributor.authorDrummond, Marina Rovani-
dc.contributor.authorLania, Bruno Grosselli-
dc.contributor.authorLins, Karina de Almeida-
dc.contributor.authorSoares, Tânia Cristina Benetti-
dc.contributor.authorVelho, Paulo Eduardo Neves Ferreira-
dc.subjectBartonellapt_BR
dc.subject.otherlanguageBartonellapt_BR
dc.description.abstractBartonella spp. are neglected fastidious Gram‐negative bacilli. We isolated Bartonella henselae from 1.2% of 500 studied blood donors and demonstrated that the bacteria remain viable in red blood cell units after 35 days of experimental infection. Now, we aim to evaluate the possibility of B. henselae transmission by blood transfusion in a mouse model. STUDY DESIGN AND METHODS Eight BALB/c mice were intraperitoneal inoculated with a 30 µL of suspension with 104 CFU/mL of B. henselae and a second group of eight mice were inoculated with saline solution and used as control. After 96 hours of inoculation, the animals were euthanized. We collected blood and tissue samples from skin, liver, and spleen. Thirty microliters of blood from four Bartonella‐inoculated animals were transfused into a new group (n = 4). Another group received blood from the control animals. B. henselae infection was investigated by conventional and nested polymerase chain reaction (PCR). RESULTS Blood samples from all 24 mice were negative by molecular tests though half of the tissue samples were positive by nested PCR in the intraperitoneal Bartonella‐investigated animals. Tissues from two of the four mice that received blood transfusions from Bartonella‐inoculated animals were also nested PCR positives. CONCLUSIONS Transmission of B. henselae by transfusion is possible in mice even when donor animals have undetectable bloodstream infection. The impact of human Bartonella sp. transmission through blood transfusion recipients must be evaluatedpt_BR
dc.relation.ispartofTransfusionpt_BR
dc.publisher.cityHoboken, NJpt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherWileypt_BR
dc.date.issued2016-
dc.date.monthofcirculationJunept_BR
dc.language.isoengpt_BR
dc.description.volume56pt_BR
dc.description.issuenumber6pt2pt_BR
dc.description.firstpage1556pt_BR
dc.description.lastpage1559pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0041-1132pt_BR
dc.identifier.eissn1537-2995pt_BR
dc.identifier.doi10.1111/trf.13545pt_BR
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/full/10.1111/trf.13545pt_BR
dc.description.sponsorshipCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumber2012/2042pt_BR
dc.description.sponsordocumentnumber2012/22340-5pt_BR
dc.date.available2021-02-18T20:01:42Z-
dc.date.accessioned2021-02-18T20:01:42Z-
dc.description.provenanceSubmitted by Thais de Brito Barroso (tbrito@unicamp.br) on 2021-02-18T20:01:42Z No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2021-02-18T20:01:42Z (GMT). No. of bitstreams: 0 Previous issue date: 2016en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/356111-
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentDepartamento de Clínica Médicapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeCentro Multidisciplinar para Investigação Biológica na Área da Ciência de Animais de Laboratóriopt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.identifier.source000380361600010pt_BR
dc.creator.orcid0000-0001-6626-5632pt_BR
dc.creator.orcid0000-0001-8036-6616pt_BR
dc.creator.orcid0000-0002-7767-691Xpt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcid0000-0001-6849-608Xpt_BR
dc.creator.orcid0000-0003-4949-7444pt_BR
dc.creator.orcid0000-0002-7236-3711pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcid0000-0001-7901-2351pt_BR
dc.type.formArtigopt_BR
Appears in Collections:FCM - Artigos e Outros Documentos
CEMIB - Artigos e Outros Documentos

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