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|Title:||Identification of ANLN as ETV6 partner gene in recurrent T(7;12)(P15;P13): a possible role of deregulated ANLN expression in leukemogenesis|
|Author:||Campregher, Paulo Vidal|
Pereira, Welbert de Oliveira
Ascendino da Mata, Evelyn Helena
Datoguia, Tarcila Santos
Rodrigues Pereira Velloso, Elvira Deolinda
Bacal, Nydia Strachman
Ross, Jeffrey S.
Costa, Fernando Ferreira
de Souza Santos, Fabio Pires
|Abstract:||The ETV6 gene encodes an ETS family transcription factor that is involved in a myriad of chromosomal rearrangements found in hematological malignancies and other neoplasms. A recurrent ETV6 translocation, previously described in patients with acute myeloid leukemia (AML) (Genes Chromosomes Cancer 51:328-337,2012, Leuk Res 35:e212-214, 2011), whose partner has not been identified is t(7; 12)(p15; p13). We herein report that the t(7; 12)(p15; p13) fuses ETV6 to ANLN, a gene not previously implicated in the pathogenesis of hematological malignancies, and we demonstrate that this translocation leads to high expression of the fusion transcript in the myeloid and lymphoid lineages|
|Subject:||Leucemia mielóide aguda|
|Appears in Collections:||FCM - Artigos e Outros Documentos|
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