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Type: Outro documento
Title: Identification of ANLN as ETV6 partner gene in recurrent T(7;12)(P15;P13): a possible role of deregulated ANLN expression in leukemogenesis
Author: Campregher, Paulo Vidal
Pereira, Welbert de Oliveira
Lisboa, Bianca
Puga, Renato
Helman, Ricardo
Miyagi, Mariana
Ascendino da Mata, Evelyn Helena
Datoguia, Tarcila Santos
Rodrigues Pereira Velloso, Elvira Deolinda
Bacal, Nydia Strachman
Ross, Jeffrey S.
Ali, Siraj
Miller, Vincent
Costa, Fernando Ferreira
Hamerschlak, Nelson
de Souza Santos, Fabio Pires
Abstract: The ETV6 gene encodes an ETS family transcription factor that is involved in a myriad of chromosomal rearrangements found in hematological malignancies and other neoplasms. A recurrent ETV6 translocation, previously described in patients with acute myeloid leukemia (AML) (Genes Chromosomes Cancer 51:328-337,2012, Leuk Res 35:e212-214, 2011), whose partner has not been identified is t(7; 12)(p15; p13). We herein report that the t(7; 12)(p15; p13) fuses ETV6 to ANLN, a gene not previously implicated in the pathogenesis of hematological malignancies, and we demonstrate that this translocation leads to high expression of the fusion transcript in the myeloid and lymphoid lineages
Subject: Leucemia mielóide aguda
Translocação genética
Country: Reino Unido
Editor: BioMed Central
Rights: Aberto
Identifier DOI: 10.1186/s12943-015-0471-5
Date Issue: 2015
Appears in Collections:FCM - Artigos e Outros Documentos

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