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Type: Artigo
Title: Comparing the antileishmanial activity of gold(I) and gold(III) compounds in L. amazonensis and L. braziliensis in vitro
Author: Minori, Karen
Rosa, Letícia B.
Bonsignore, Riccardo
Casini, Angela
Miguel, Danilo C.
Abstract: A series of mononuclear coordination or organometallic AuI/AuIII complexes (1–9) have been comparatively studied in vitro for their antileishmanial activity against promastigotes and amastigotes, the clinically relevant parasite form, of Leishmania amazonensis and Leishmania braziliensis. One of the cationic AuI bis‐N‐heterocyclic carbenes (3) has low EC50 values (ca. 4 μM) in promastigotes cells and no toxicity in host macrophages. Together with two other AuIII complexes (6 and 7), the compound is also extremely effective in intracellular amastigotes from L. amazonensis. Initial mechanistic studies include an evaluation of the gold complexes′ effect on L. amazonensis’ plasma membrane integrity
Subject: Compostos de ouro
Country: Alemanha
Editor: John Wiley & Sons
Rights: Fechado
Identifier DOI: 10.1002/cmdc.202000536
Date Issue: 2020
Appears in Collections:IB - Artigos e Outros Documentos

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