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Type: Outro documento
Title: αB‐Crystallin interacts and attenuates the tyrosine phosphatase activity of Shp2 in cardiomyocytes under mechanical stress
Author: Gonçalves, Danieli C.
Marin, Talita M.
Pereira, Michelle B. M.
Santos, Aline M.
Leme, Adriana F. Paes
Franchini, Kleber G.
Abstract: The small heat shock protein αB‐Crystallin (CryAB, HspB5) and SH2 domain‐containing tyrosine phosphatase 2 (Shp2) are important molecules in heart response to pathophysiological stress. Here we show that CryAB interacts with and potentially regulates Shp2 catalytic activity in stretched cardiomyocytes. Such an interaction requires CryAB oligomer to attenuate Shp2 activation. Stretched cardiomyocytes show a robust CryAB/Shp2 association accompanied by a reduction in the Shp2 phosphatase activity. Accordingly, CryAB knock‐down in cardiomyocytes enhances Shp2 activity induced by mechanical stress. These results revealed a new role for CryAB, as a modulator of Shp2 phosphatase activity during a functionally relevant stimulus in cardiomyocytes
Subject: Miócitos cardíacos
Country: Reino Unido
Editor: John Wiley & Sons
Rights: Fechado
Identifier DOI: 10.1002/1873-3468.12235
Date Issue: 2016
Appears in Collections:IB - Artigos e Outros Documentos
FCM - Artigos e Outros Documentos

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