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|Title:||The structure of a trypanosoma cruzi glucose‐6‐phosphate dehydrogenase reveals differences from the mammalian enzyme|
|Author:||Mercaldi, Gustavo F.|
Hunter, Willian N.
Cordeiro, Artur T.
|Abstract:||The enzyme glucose‐6‐phosphate dehydrogenase from Trypanosoma cruzi (TcG6PDH) catalyses the first step of the pentose phosphate pathway (PPP) and is considered a promising target for the discovery of a new drug against Chagas diseases. In the present work, we describe the crystal structure of TcG6PDH obtained in a ternary complex with the substrate β‐d‐glucose‐6‐phosphate (G6P) and the reduced ‘catalytic’ cofactor NADPH, which reveals the molecular basis of substrate and cofactor recognition. A comparison with the homologous human protein sheds light on differences in the cofactor‐binding site that might be explored towards the design of new NADP+ competitive inhibitors targeting the parasite enzyme|
|Subject:||Doença de Chagas|
|Editor:||John Wiley & Sons|
|Appears in Collections:||CNPEM - Artigos e Outros Documentos|
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