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Type: Outro documento
Title: The structure of a trypanosoma cruzi glucose‐6‐phosphate dehydrogenase reveals differences from the mammalian enzyme
Author: Mercaldi, Gustavo F.
Dawson, Alice
Hunter, Willian N.
Cordeiro, Artur T.
Abstract: The enzyme glucose‐6‐phosphate dehydrogenase from Trypanosoma cruzi (TcG6PDH) catalyses the first step of the pentose phosphate pathway (PPP) and is considered a promising target for the discovery of a new drug against Chagas diseases. In the present work, we describe the crystal structure of TcG6PDH obtained in a ternary complex with the substrate β‐d‐glucose‐6‐phosphate (G6P) and the reduced ‘catalytic’ cofactor NADPH, which reveals the molecular basis of substrate and cofactor recognition. A comparison with the homologous human protein sheds light on differences in the cofactor‐binding site that might be explored towards the design of new NADP+ competitive inhibitors targeting the parasite enzyme
Subject: Doença de Chagas
Country: Reino Unido
Editor: John Wiley & Sons
Rights: Fechado
Identifier DOI: 10.1002/1873-3468.12276
Date Issue: 2016
Appears in Collections:CNPEM - Artigos e Outros Documentos

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