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Type: Artigo
Title: Purification methodology for viable and infective Plasmodium vivax gametocytes that is compatible with transmission-blocking assays
Author: Vera, Omaira
de Brito, Paula Brelas
Albrecht, Letusa
Monick Martins-Campos, Keillen
Pimenta, Paulo F. P.
Monteiro, Wuelton M.
Lacerda, Marcus V. G.
Lopes, Stefanie C. P.
Costa, Fabio T. M.
Abstract: Significant progress toward the control of malaria has been achieved, especially regarding Plasmodium falciparum infections. However, the unique biology of Plasmodium vivax hampers current control strategies. The early appearance of P. vivax gametocytes in the peripheral blood and the impossibility of culturing this parasite are major drawbacks. Using blood samples from 40 P. vivax-infected patients, we describe here a methodology to purify viable gametocytes and further infect anophelines. This method opens new avenues to validate transmission-blocking strategies
Subject: Plasmodium vivax
Country: Estados Unidos
Editor: American Society for Microbiology
Rights: Fechado
Identifier DOI: 10.1128/AAC.01136-15
Date Issue: 2015
Appears in Collections:IB - Artigos e Outros Documentos

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