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Type: Artigo
Title: Potential role of CC chemokine receptor 6 in prediction of late-onset Cytomegalovirus infection following solid organ transplant
Author: Camargo, Jose F.
Resende, Mariangela R.
Zamel, Ricardo
Klement, William
Bhimji, Alyajahan
Huibner, Sanja
Kumar, Deepali
Humar, Atul
Jurisica, Igor
Keshavjee, Shaf
Kaul, Rupert
Husain, Shahid
Abstract: CCR6 is a chemokine receptor involved in homing memory T cells, particularly Th17 cells, to sites of mucosal inflammation. Despite the critical role of memory T cells in long-term protective immunity against cytomegalovirus (CMV), a virus that reactivates at multiple mucosal sites, the ability of CCR6 or other Th17 marker expression to predict CMV reactivation following transplantation is not clear. Using 11-color flow cytometry, in this prospective single-center pilot study, we measured the expression of CCR6 and other markers of T-cell function in peripheral blood samples obtained from 21 SOT recipients at the time of discontinuation of anti-CMV prophylaxis. CMV viremia was monitored on a monthly basis after discontinuation of prophylaxis. Eleven patients (52%) developed CMV viremia during the six-month follow-up period. Late-onset CMV infection was preceded by an immune phenotype characterized by increased CCR6 expression on bulk CD4(+) T cells and a reduced number of circulating CMV IE-1-specific Th1 (CD4(+)IFN-(+)) cells. Among the markers evaluated, CCR6 was the best single predictor of late-onset CMV infection. Our results suggest that CCR6 expression at the time of discontinuation of antiviral prophylaxis might be a useful predictor of late-onset CMV reactivation and provide the basis for future larger prospective studies
Subject: Citomegalovírus
Linfócitos T
Country: Estados Unidos
Editor: Wiley
Rights: Fechado
Identifier DOI: 10.1111/ctr.12531
Date Issue: 2015
Appears in Collections:FCM - Artigos e Outros Documentos

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