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Type: Artigo
Title: A Brazilian multicentre study evaluating pregnancies induced by cabergoline in patients harboring prolactinomas
Author: Sant’ Anna, B. G.
Musolino, N. R. C.
Gadelha, M. R.
Marques, C.
Castro, M.
Elias, P. C. L.
Vilar, L.
Lyra, R.
Martins, M. R. A.
Quidute, A. R. P.
Abucham, J.
Nazato, D.
Garmes, H. M.
Fontana, M. L. C.
Boguszewski, C. L.
Bueno, C. B.
Czepielewski, M. A.
Portes, E. S.
Nunes-Nogueira, V. S.
Ribeiro-Oliveira Jr., A.
Francisco, R. P. V.
Bronstein, M. D.
Glezer, A.
Abstract: To evaluate the maternal–fetal outcomes of CAB-induced pregnancies in patients with prolactinoma in a large cohort.The prevalence of tumor growth, miscarriage, preterm, low birth weight, congenital malformations and impairment in neuropsychological development in children among women treated with CAB were assessed in a Brazilian multicentre retrospective observational study. We included 194 women with a mean age of 31 (17–45) years, 43.6% presenting microadenomas and 56.4% macroadenomas, at prolactinoma diagnosis. In 233 pregnancies, CAB was withdrawn in 89%, after pregnancy confirmation. Symptoms related to tumor growth occurred in 25 cases, more frequently in macroadenomas. The overall miscarriage rate was 11%, although higher in the subgroup of patients with CAB maintainance after pregnancy confirmation (38% vs. 7.5%). Amongst the live-birth deliveries, preterm occurred in 12%, low birth weight in 6% and congenital malformations in 4.3%. Neuropsychological development impairment was reported in 7% of cases. Our findings confirm previous results of safety in maternal and fetal outcomes in CAB-induced pregnancies; nevertheless, CAB maintenance after pregnancy confirmation was associated with higher miscarriage rate; result that must be further confirmed
Subject: Estudo clínico
Country: Estados Unidos
Editor: Springer
Rights: Fechado
Identifier DOI: 10.1007/s11102-019-01008-z
Date Issue: 2020
Appears in Collections:FCM - Artigos e Outros Documentos

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