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http://repositorio.unicamp.br/jspui/handle/REPOSIP/355673
Type: | Artigo |
Title: | A Brazilian multicentre study evaluating pregnancies induced by cabergoline in patients harboring prolactinomas |
Author: | Sant’ Anna, B. G. Musolino, N. R. C. Gadelha, M. R. Marques, C. Castro, M. Elias, P. C. L. Vilar, L. Lyra, R. Martins, M. R. A. Quidute, A. R. P. Abucham, J. Nazato, D. Garmes, H. M. Fontana, M. L. C. Boguszewski, C. L. Bueno, C. B. Czepielewski, M. A. Portes, E. S. Nunes-Nogueira, V. S. Ribeiro-Oliveira Jr., A. Francisco, R. P. V. Bronstein, M. D. Glezer, A. |
Abstract: | To evaluate the maternal–fetal outcomes of CAB-induced pregnancies in patients with prolactinoma in a large cohort.The prevalence of tumor growth, miscarriage, preterm, low birth weight, congenital malformations and impairment in neuropsychological development in children among women treated with CAB were assessed in a Brazilian multicentre retrospective observational study. We included 194 women with a mean age of 31 (17–45) years, 43.6% presenting microadenomas and 56.4% macroadenomas, at prolactinoma diagnosis. In 233 pregnancies, CAB was withdrawn in 89%, after pregnancy confirmation. Symptoms related to tumor growth occurred in 25 cases, more frequently in macroadenomas. The overall miscarriage rate was 11%, although higher in the subgroup of patients with CAB maintainance after pregnancy confirmation (38% vs. 7.5%). Amongst the live-birth deliveries, preterm occurred in 12%, low birth weight in 6% and congenital malformations in 4.3%. Neuropsychological development impairment was reported in 7% of cases. Our findings confirm previous results of safety in maternal and fetal outcomes in CAB-induced pregnancies; nevertheless, CAB maintenance after pregnancy confirmation was associated with higher miscarriage rate; result that must be further confirmed |
Subject: | Estudo clínico |
Country: | Estados Unidos |
Editor: | Springer |
Rights: | Fechado |
Identifier DOI: | 10.1007/s11102-019-01008-z |
Address: | https://link.springer.com/article/10.1007/s11102-019-01008-z |
Date Issue: | 2020 |
Appears in Collections: | FCM - Artigos e Outros Documentos |
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