Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/355626
Type: Artigo
Title: Mechanical competence of ovariectomy-induced compromised bone after single or combined treatment With high-frequency loading and bisphosphonates
Author: Camargos, G. V.
Bhattacharya, P.
van Lenthe, G. H.
Del Bel Cury, A. A.
Naert, I.
Duyck, J.
Vandamme, K.
Abstract: Osteoporosis leads to increased bone fragility, thus effective approaches enhancing bone strength are needed. Hence, this study investigated the effect of single or combined application of high-frequency (HF) loading through whole body vibration (WBV) and alendronate (ALN) on the mechanical competence of ovariectomy-induced osteoporotic bone. Thirty-four female Wistar rats were ovariectomized (OVX) or sham-operated (shOVX) and divided into five groups: shOVX, OVX-shWBV, OVX-WBV, ALN-shWBV and ALN-WBV. (Sham) WBV loading was applied for 10 min/day (130 to 150 Hz at 0.3g) for 14 days and ALN at 2 mg/kg/dose was administered 3x/week. Finite element analysis based on micro-CT was employed to assess bone biomechanical properties, relative to bone micro-structural parameters. HF loading application to OVX resulted in an enlarged cortex, but it was not able to improve the biomechanical properties. ALN prevented trabecular bone deterioration and increased bone stiffness and bone strength of OVX bone. Finally, the combination of ALN with HF resulted in an increased cortical thickness in OVX rats when compared to single treatments. Compared to HF loading, ALN treatment is preferred for improving the compromised mechanical competence of OVX bone. In addition, the association of ALN with HF loading results in an additive effect on the cortical thickness
Subject: Alendronato
Fraturas
Análise de elementos finitos
Densidade óssea
Country: Reino Unido
Editor: Springer Nature
Rights: Aberto
Identifier DOI: 10.1038/srep10795
Address: https://www.nature.com/articles/srep10795
Date Issue: 2015
Appears in Collections:FOP - Artigos e Outros Documentos

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