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Type: Artigo
Title: Characterization of the release profile of doxycycline by PLGA microspheres adjunct to non-surgical periodontal therapy
Author: Moura, Lucas Alves
Ribeiro, Fernanda Vieira
Aiello, Talita Bianchi
Duek, Eliana Ap. de Rezende
Sallum, Enilson Antonio
Nociti Junior, Francisco Humberto
Casati, Márcio Zaffalon
Sallum, Antonio Wilson
Abstract: The aim of this pilot study was to assess the release of locally delivered doxycycline by poly (l-lactide-co-glycolide) (PLGA) microspheres in the periodontal pocket of patients with chronic periodontitis, treated by non-surgical periodontal therapy. Nineteen sites of non-adjacent teeth of four different patients were evaluated. Five milligram of PLGA microspheres loaded with 16 doxycycline hyclate (DOX) was administered per periodontal site. To quantify DOX released into the periodontal pocket, gingival crevicular fluid (GCF) was collected from the sites on days 2, 5, 7, 10, 15, and 20 after DOX application, and high-performance liquid chromatography was performed. Data were statistically assessed by ANOVA/Tukey test. At days 2, 5, and 7, the DOX concentration was stably sustained (23.33 ± 1.38, 23.4 ± 1.82, and 22.75 ± 1.33 μg/mL, respectively), with no significant differences over these assessment times (p > 0.05). At days 10 and 15, a tendency was observed toward a decrease in DOX concentration (21.74 ± 0.91 and 20.53 ± 4.88 μg/mL, respectively), but a significant decrease in GCF drug concentration (19.69 ± 4.70 μg/mL) was observed only on day 20. The DOX delivery system developed demonstrated a successful sustained release after local administration, as an adjunct to non-surgical periodontal therapy
Subject: Microesferas
Country: Reino Unido
Editor: Taylor & Francis
Rights: Fechado
Identifier DOI: 10.1080/09205063.2015.1045249
Date Issue: 2015
Appears in Collections:FOP - Artigos e Outros Documentos

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