Please use this identifier to cite or link to this item:
Type: Artigo
Title: Reduced graphene oxide induces transient blood–brain barrier opening: an in vivo study
Author: Mendonça, Monique Culturato Padilha
Soares, Edilene Siqueira
Jesus, Marcelo Bispo de
Ceragioli, Helder José
Ferreira, Mônica Siqueira
Catharino, Rodrigo Ramos
Cruz-Höfling, Maria Alice da
Abstract: The blood–brain barrier (BBB) is a complex physical and functional barrier protecting the central nervous system from physical and chemical insults. Nevertheless, it also constitutes a barrier against therapeutics for treating neurological disorders. In this context, nanomaterial-based therapy provides a potential alternative for overcoming this problem. Graphene family has attracted significant interest in nanomedicine because their unique physicochemical properties make them amenable to applications in drug/gene delivery and neural interface. In this study, reduced graphene oxide (rGO) systemically-injected was found mainly located in the thalamus and hippocampus of rats. The entry of rGO involved a transitory decrease in the BBB paracellular tightness, as demonstrated at anatomical (Evans blue dye infusion), subcellular (transmission electron microscopy) and molecular (junctional protein expression) levels. Additionally, we examined the usefulness of matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) as a new imaging method for detecting the temporal distribution of nanomaterials throughout the brain.rGO was able to be detected and monitored in the brain over time provided by a novel application for MALDI-MSI and could be a useful tool for treating a variety of brain disorders that are normally unresponsive to conventional treatment because of BBB impermeability
Subject: Óxido de grafeno
Country: Reino Unido
Editor: BioMed Central
Rights: Fechado
Identifier DOI: 10.1186/s12951-015-0143-z
Date Issue: 2015
Appears in Collections:IB - Artigos e Outros Documentos
FCM - Artigos e Outros Documentos
FEEC - Artigos e Outros Documentos
FCF - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
000363737900001.pdf2.45 MBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.