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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampBiller, Priscila do Nascimento-
dc.typeArtigopt_BR
dc.titleMoments of genome evolution by double cut-and-joinpt_BR
dc.contributor.authorBiller, Priscila-
dc.contributor.authorGuéguen, Laurent-
dc.contributor.authorTannier, Eric-
dc.subjectPermutações (Matemática)pt_BR
dc.subject.otherlanguagePermutations (Mathematics)pt_BR
dc.description.abstractWe study statistical estimators of the number of genomic events separating two genomes under a Double Cut-and Join (DCJ) rearrangement model, by a method of moment estimation. We first propose an exact, closed, analytically invertible formula for the expected number of breakpoints after a given number of DCJs. This improves over the heuristic, recursive and computationally slower previously proposed one. Then we explore the analogies of genome evolution by DCJ with evolution of binary sequences under substitutions, permutations under transpositions, and random graphs. Each of these are presented in the literature with intuitive justifications, and are used to import results from better known fields. We formalize the relations by proving a correspondence between moments in sequence and genome evolution, provided substitutions appear four by four in the corresponding model. Eventually we prove a bounded error on two estimators of the number of cycles in the breakpoint graph after a given number of rearrangements, by an analogy with cycles in permutations and components in random graphspt_BR
dc.relation.ispartofBMC bioinformaticspt_BR
dc.publisher.cityLondonpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherSpringer Naturept_BR
dc.date.issued2015-
dc.date.monthofcirculationOct.pt_BR
dc.language.isoengpt_BR
dc.description.volume16pt_BR
dc.rightsAbertopt_BR
dc.sourceWOSpt_BR
dc.identifier.eissn1471-2105pt_BR
dc.identifier.doi10.1186/1471-2105-16-S14-S7pt_BR
dc.identifier.urlhttps://bmcbioinformatics.biomedcentral.com/articles/10.1186/1471-2105-16-S14-S7pt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumber2013/25084-2pt_BR
dc.date.available2021-02-10T17:31:22Z-
dc.date.accessioned2021-02-10T17:31:22Z-
dc.description.provenanceSubmitted by Susilene Barbosa da Silva (susilene@unicamp.br) on 2021-02-10T17:31:22Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-05-24T19:06:47Z : No. of bitstreams: 1 000367880100007.pdf: 1257839 bytes, checksum: f8b33ea4e66aa42d0a5934d89736c6b5 (MD5)en
dc.description.provenanceMade available in DSpace on 2021-02-10T17:31:22Z (GMT). No. of bitstreams: 0 Previous issue date: 2015en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/355526-
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.unidadeInstituto de Computaçãopt_BR
dc.identifier.source000367880100007pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.type.formArtigo de pesquisapt_BR
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