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Type: Artigo
Title: LDH and age are associated with hemolysis-endothelial dysfunction in HbSC patients
Author: Gilli, Simone Cristina Olenscki
Bastos, Stephany Oliveira
Benites, Bruno Deltreggia
Costa, Fernando Ferreira
Saad, Sara Teresinha Olalla
Abstract: Despite not yet explored, the serum lactate dehydrogenase (LDH) level in hemoglobinopathy SC (HbSC) patients could be a marker of disease severity as this association is strong in sickle cell patients. We hypothesized that the degree of hemolysis in HbSC patients is a key determinant influencing a spectrum of complications that reflect the severity of HbSC vasculopathy. The aim of this study was to analyze the associations between hemolytic parameters and chronic complications in adult SC patients. Findings We demonstrated that LDH reflects the overall rate of hemolysis and presents a correlation with the complications related to the hemolytic subphenotype: retinopathy, venous thromboembolism and leg ulcers in HbSC patients. Remarkably, this simple biomarker was associated with a clinical subphenotype of complications in patients with HbSC disease. Conclusions We propose that LDH elevation identifies HbSC patients with hemolysis, which could be a marker of endothelial dysfunction and end-organ vasculopathy. The use of this test as a marker of disease severity could complement the decisions taken during HbSC patient management
Subject: Hemólise
Country: Países Baixos
Editor: Elsevier
Rights: Fechado
Identifier DOI: 10.1016/j.bcmd.2016.04.012
Date Issue: 2016
Appears in Collections:FCM - Artigos e Outros Documentos
HEMO - Artigos e Outros Documentos

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