Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/355472
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampDutra, Sabrina Nogueira-
dc.typeArtigopt_BR
dc.titleA comparative study using WHO and binary oral epithelial dysplasia grading systems in actinic cheilitispt_BR
dc.contributor.authorCâmara, PR-
dc.contributor.authorDutra, SN-
dc.contributor.authorTakahama Júnior, A-
dc.contributor.authorFontes, KBFC-
dc.contributor.authorAzevedo, RS-
dc.subjectOrganização Mundial da Saúdept_BR
dc.subject.otherlanguageWorld Health Organizationpt_BR
dc.description.abstractTo evaluate comparatively the influence of histopathological features on epithelial dysplasia (ED) and the effectiveness in usage of WHO and binary grading systems in actinic cheilitis (AC). Cytological and architectural alterations established by WHO for ED were evaluated in 107 cases of AC. Epithelial dysplasia was graded using WHO and binary systems. The comparisons were performed using kappa, chi‐square, and phi coefficient tests (P < 0.05). Most cases were classified as mild ED (44.5%) in the WHO system and as low risk for malignant transformation (64.5%) in the binary system. There was a positive correlation between WHO and binary systems (k = 0.33; P < 0.0002). Loss of basal cell polarity (P < 0.001) was associated with severity of ED grade in the WHO system. Anisonucleosis (P < 0.0001), nuclear pleomorphism (P < 0.0001), anisocytosis (P = 0.03), cell pleomorphism (P = 0.002) increased nuclear/cytoplasm ratio (P < 0.0001), increased nuclear size (P < 0.0001), increased number of mitotic figures (P = 0.0006), and dyskeratosis (P = 0.008) were associated with severity of ED grade in the binary system. It seems that usage of binary ED grading system in AC may be more precise because there is correlation between many of cytological and some of architectural microscopic alterations with increased grade of ED.pt_BR
dc.relation.ispartofOral diseasespt_BR
dc.relation.ispartofabbreviationOral. dis.pt_BR
dc.publisher.cityHoboken, NJpt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherWileypt_BR
dc.date.issued2016-
dc.date.monthofcirculationSept.pt_BR
dc.language.isoengpt_BR
dc.description.volume22pt_BR
dc.description.issuenumber6pt_BR
dc.description.firstpage523pt_BR
dc.description.lastpage529pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn1354-523Xpt_BR
dc.identifier.eissn1601-0825pt_BR
dc.identifier.doi10.1111/odi.12484pt_BR
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/full/10.1111/odi.12484pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipFUNDAÇÃO CARLOS CHAGAS FILHO DE AMPARO À PESQUISA DO ESTADO DO RIO DE JANEIRO - FAPERJpt_BR
dc.description.sponsordocumentnumberSem informaçãopt_BR
dc.description.sponsordocumentnumberSem informaçãopt_BR
dc.date.available2021-02-10T10:17:39Z-
dc.date.accessioned2021-02-10T10:17:39Z-
dc.description.provenanceSubmitted by Bruna Maria Campos da Cunha (bcampos@unicamp.br) on 2021-02-10T10:17:38Z No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2021-02-10T10:17:39Z (GMT). No. of bitstreams: 0 Previous issue date: 2016en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/355472-
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.identifier.source000381044200009pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.type.formArtigo originalpt_BR
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