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Type: Artigo
Title: NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice
Author: Zhang, Hongbo
Ryu, Dongryeol
Wu, Yibo
Gariani, Karim
Wang, Xu
Luan, Peiling
D’Amico, Davide
Ropelle, Eduardo R.
Lutolf, Matthias P.
Aebersold, Ruedi
Schoonjans, Kristina
Menzies, Keir J.
Auwerx, Johan
Abstract: Adult stem cells (SCs) are essential for tissue maintenance and regeneration yet are susceptible to senescence during aging. We demonstrate the importance of the amount of the oxidized form of cellular nicotinamide adenine dinucleotide (NAD+) and its effect on mitochondrial activity as a pivotal switch to modulate muscle SC (MuSC) senescence. Treatment with the NAD+ precursor nicotinamide riboside (NR) induced the mitochondrial unfolded protein response and synthesis of prohibitin proteins, and this rejuvenated MuSCs in aged mice. NR also prevented MuSC senescence in the mdx (C57BL/10ScSn-Dmdmdx/J) mouse model of muscular dystrophy. We furthermore demonstrate that NR delays senescence of neural SCs and melanocyte SCs and increases mouse life span. Strategies that conserve cellular NAD+ may reprogram dysfunctional SCs and improve life span in mammals
Subject: Mitocôndria
Country: Estados Unidos
Editor: American Association for the Advancement of Science
Rights: Fechado
Identifier DOI: 10.1126/science.aaf2693
Date Issue: 2016
Appears in Collections:FCA - Artigos e Outros Documentos

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