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Type: Artigo
Title: Low-density lipoprotein cholesterol is associated with asymptomatic sensorineural hearing loss in patients with systemic lupus erythematosus
Author: Ferrari, Ana Luisa V.
Calonga, L.
Lapa, Aline T.
Postal, Mariana
Sinicato, Nailu A.
Peliçari, Karina O.
Peres, Fernando A.
Valente, João Paulo
Soki, Marcelo
Appenzeller, Simone
Costallat, Lilian T. L.
Abstract: The aims of this study were to determine the frequency of asymptomatic sensorineural hearing loss (SNHL) in systemic lupus erythematosus (SLE) and to determine the association between SNHL and demographic, clinical, and laboratory features and cardiovascular risk factors. Methods We conducted a cross-sectional study including consecutive female SLE patients. We performed audiometry and clinical and laboratory evaluation and determined cardiovascular risk factors in all patients. Statistical analysis included principal component analysis and logistic regression. Results Eighty-nine women were included with mean age of 38.98 (SD, 7.77) years and mean disease duration of 10.29 (SD, 9.19) years. Asymptomatic SNHL was observed in 14 patients (16%). In logistic regression model, only low-density lipoprotein levels (z = 2.64; P = 0.008) were associated with SNHL. Conclusions We observed asymptomatic SNHL in 16% of SLE and an association with low-density lipoprotein levels suggesting atherosclerosis as a mechanism. Follow-up is needed to determine clinical implications
Subject: HDL-colesterol
Country: Estados Unidos
Editor: Lippincott Williams & Wilkins
Rights: Fechado
Identifier DOI: 10.1097/RHU.0000000000000382
Date Issue: 2016
Appears in Collections:FCM - Artigos e Outros Documentos

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