Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/355369
Type: Artigo
Title: Use of cystatin c and serum creatinine for the diagnosis of contrast-induced nephropathy in patients undergoing contrast-enhanced computed tomography at an oncology centre
Title Alternative: Use of cystatin c and serum creatinine for the diagnosis of contrast-induced nephropathy in patients undergoing contrast-enhanced computed tomography at an oncology centre
Author: Melo, Joao Italo Fortalesa
Chojniak, Rubens
Silva, Debora Helena Costa
Oliveira Junior, Jose Carlos
Bitencourt, Almir Galvão Vieira
Silva, Diego Holanda
Guimarães, Marcos Duarte
Silva, Hernandes Cerqueira Souza
Dias, Denis Guilherme Teixeira
Rodrigues, Winglison Carli
Brancucci, Ellen Luzia
Cruz, Barbara Martins Soares
Schiavon, Beatriz Nunes
Argenton, Juliana Luz Passos
Camporini, Margareth Arrivabene
Zocchio, Adriana
Abstract: Our aim was to assess renal function using as laboratory measurements serum creatinine and cystatin C concentrations before and after administration of low-osmolarity (nonionic) iodinated contrast medium in patients with cancer undergoing computed tomography (CT). This prospective study included 400 oncologic outpatients. Serum creatinine and cystatin C concentrations were measured before and 72 h after contrast administration. Glomerular filtration rates (GFRs) were estimated using serum creatinine–based [Modification of Diet in Renal Disease (MDRD) and Cockroft-Gault and cystatin C based (Larsson) equations. Exploratory data analysis was performed. The nonparametric Wilcoxon test was used to compare pre and post contrast of test results and estimated clearance. The confidence interval used in the analysis was 95%. Compared with the pre-contrast values, the mean serum creatinine concentration was significantly higher and average GFRs estimated using MDRD and Cockcroft-Gault equations were significantly lower after the administration of contrast (p <0.001). It was also observed a significant increase after contrast in the concentration of Cystatin C (p = 0.015). In addition, a decrease in GFR estimated using the average Larsson (p = 0.021) was observed between time points. However, none of the patients presented clinically significant nephropathy. Assessment using serum creatinine and cystatin C concentrations showed changes in renal function among patients with cancer undergoing contrast-enhanced CT examination in this study. No significant renal damage related to the use of low-osmolarity iodinated contrast medium of the type and dosage employed in this study was observed. This contrast medium is thus safe for use in patients with cancer
Subject: Creatinina
Country: Estados Unidos
Editor: Public Library of Science
Rights: Aberto
Identifier DOI: 10.1371/journal.pone.0122877
Address: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0122877
Date Issue: 2015
Appears in Collections:FCM - Artigos e Outros Documentos

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