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Type: Artigo
Title: Association of the immature platelet fraction with sepsis diagnosis and severity
Author: Enz Hubert, Rodolfo Monteiro
Rodrigues, Melina Veiga
Andreguetto, Bruna Dolci
Santos, Thiago M.
Pereira Gilberti, Maria de Fatima
de Castro, Vagner
Annichino-Bizzacchi, Joyce M.
Dragosavac, Desanka
Carvalho-Filho, Marco Antonio
De Paula, Erich Vinicius
Abstract: Management of Sepsis would greatly benefit from the incorporation of simple and informative new biomarkers in clinical practice. Ideally, a sepsis biomarker should segregate infected from non-infected patients, provide information about prognosis and organ-specific damage, and be accessible to most healthcare services. The immature platelet fraction (IPF) and immature reticulocyte fraction (IRF) are new analytical parameters of the complete blood count, that have been studied as biomarkers of several inflammatory conditions. Recently, a study performed in critically-ill patients suggested that IPF could be a more accurate sepsis biomarker than C-reactive protein (CRP) and procalcitonin. In this retrospective study we evaluated the performance of IPF and IRF as biomarkers of sepsis diagnosis and severity. 41 patients admitted to two intensive care units were evaluated, 12 of which with severe sepsis or septic shock, and 11 with non-complicated sepsis. Significantly higher IPF levels were observed in patients with severe sepsis/septic shock. IPF correlated with sepsis severity scores and presented the highest diagnostic accuracy for the presence of sepsis of all studied clinical and laboratory parameters. No significant differences were observed in IRF levels. Our results suggest that IPF levels could be used as a biomarker of sepsis diagnosis and severity
Subject: Sepse
Country: Reino Unido
Editor: Springer Nature
Rights: Aberto
Identifier DOI: 10.1038/srep08019
Date Issue: 2015
Appears in Collections:FCM - Artigos e Outros Documentos
HC - Artigos e Outros Documentos
HEMO - Artigos e Outros Documentos

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