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Type: Artigo
Title: Immunohistochemical expression of GLUT-1 and HIF-1α in tooth germ, ameloblastoma, and ameloblastic carcinoma
Author: Sánchez-Romero, Celeste
Bologna-Molina, Ronell
Mosqueda-Taylor, Adalberto
Almeida, Oslei Paes de
Abstract: Hypoxia-inducible factor-1α (HIF-1α) promotes proteins that enable cell survival during hypoxia, such as glucose transporter 1 (GLUT-1). Their coexpression has been associated with aggressiveness in malignancies and has not been studied in odontogenic tumors. Immunohistochemical expression of HIF-1α and GLUT-1 was analyzed in 13 tooth germs (TGs), 55 ameloblastomas (AMs), and 3 ameloblastic carcinomas (ACs). HIF-1α was negative in all TGs, and just 1 case of AM and 1 of AC had nuclear positivity. GLUT-1 expressed in ameloblastic cells of all TGs, AMs, and ACs, with an increasing intensity, respectively, and was significantly higher in solid AM than in unicystic AM (P = .041). Absence of nuclear HIF-1α in TGs and most AMs suggest that GLUT-1 may be induced by alternative pathways to hypoxia. However, in ACs, HIF-1α may be activated; however, to confirm this, additional cases are needed. GLUT-1 overexpression could be related to aggressiveness in AMs and ACs and must represent a normal metabolite in TGs
Subject: Ameloblastoma
Country: Estados Unidos
Editor: Sage
Rights: Fechado
Identifier DOI: 10.1177/1066896916640359
Date Issue: 2016
Appears in Collections:FOP - Artigos e Outros Documentos

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