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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampCoan, Ana Carolina-
dc.contributor.authorunicampGuerreiro, Carlos Alberto Mantovani-
dc.typeArtigopt_BR
dc.titleDelineating behavioral and cognitive phenotypes in juvenile myoclonic epilepsy: are we missing the forest for the trees?pt_BR
dc.contributor.authorValente, Kette D.-
dc.contributor.authorRzezak, Patricia-
dc.contributor.authorMoschetta, Sylvie P.-
dc.contributor.authorde Vincentiis, Silvia-
dc.contributor.authorCoan, Ana C.-
dc.contributor.authorGuerreiro, Carlos A. M.-
dc.subjectEpilepsia mioclônica juvenilpt_BR
dc.subject.otherlanguageJuvenile myoclonic epilepsypt_BR
dc.description.abstractPatients with juvenile myoclonic epilepsy (JME) have executive dysfunction and impulsive traits. There are lines of evidence that JME is a heterogeneous epilepsy syndrome considering outcome. In this study, we aimed to analyze this heterogeneity beyond seizure control. The objective was to identify whether the pattern of cognitive dysfunction and impulse control is also heterogeneous, in an attempt to establish possible differences in patients with easy-and hard-to-control epilepsies. Essentially, 57 patients with JME were compared with 44 controls. Patients and controls were assessed with a neuropsychological battery for executive, attention, and memory functions. The expression of impulsive traits was evaluated with the Temperament and Character Inventory - novelty seeking domain. Then, patients were categorized according to seizure control as having easy-and hard-to-control JME. Patients with hard-to-control JME showed worse performance in 12 out of 25 neuropsychological tests than those with easy-to-control JME. Patients with hard-to-control JME also demonstrated significantly higher scores in novelty seeking -subfactor impulsiveness (p=0.002). Our study demonstrated the existence of distinct or more severe cognitive and psychiatric profiles in a subset of patients with JME. Patients with treatment-refractory seizures seem to present a broader impairment related to both cognitive deficits and impulsive traits. These findings suggest that patients with JME are not equally compromised by executive and memory deficits or dysfunction, neither by their impulsive traits. Thus, there is a need for a better characterization of patients with JME to include diverse phenotypes since our results suggest a possible existence of distinct groups of patients with JMEpt_BR
dc.relation.ispartofEpilepsy & behaviorpt_BR
dc.relation.ispartofabbreviationEpilepsy behav.pt_BR
dc.publisher.cityAmsterdampt_BR
dc.publisher.countryPaíses Baixospt_BR
dc.publisherElsevierpt_BR
dc.date.issued2015-
dc.date.monthofcirculationJan.pt_BR
dc.language.isoengpt_BR
dc.description.volume54pt_BR
dc.description.firstpage95pt_BR
dc.description.lastpage99pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn1525-5050pt_BR
dc.identifier.eissn1525-5069pt_BR
dc.identifier.doi10.1016/j.yebeh.2015.10.022pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S152550501500582Xpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsordocumentnumber307262/2011-1pt_BR
dc.description.sponsordocumentnumber05/56464-9; 07/52110-3pt_BR
dc.date.available2021-02-05T18:29:16Z-
dc.date.accessioned2021-02-05T18:29:16Z-
dc.description.provenanceSubmitted by Cintia Oliveira de Moura (cintiaom@unicamp.br) on 2021-02-05T18:29:16Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-05-25T14:38:14Z : No. of bitstreams: 1 000368425000016.pdf: 334405 bytes, checksum: b7dce7625002ac4f25cac11e847fa129 (MD5)en
dc.description.provenanceMade available in DSpace on 2021-02-05T18:29:16Z (GMT). No. of bitstreams: 0 Previous issue date: 2015en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/355304-
dc.contributor.departmentDepartamento de Neurologiapt_BR
dc.contributor.departmentDepartamento de Neurologiapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.identifier.source000368425000016pt_BR
dc.creator.orcid0000-0002-2888-929Xpt_BR
dc.creator.orcidsem informaçãopt_BR
dc.type.formPesquisa clinicapt_BR
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