Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/355277
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampMaldanis, Lara-
dc.typeArtigopt_BR
dc.titleSignaling through retinoic acid receptors in cardiac development: Doing the right things at the right timespt_BR
dc.contributor.authorXavier-Neto, Jose-
dc.contributor.authorSousa Costa, Angela M.-
dc.contributor.authorFigueira, Ana Carolina M.-
dc.contributor.authorCaiaffa, Carlo Donato-
dc.contributor.authordo Amaral, Fabio Neves-
dc.contributor.authorCerqueira Peres, Lara Maldanis-
dc.contributor.authorPires da Silva, Barbara Santos-
dc.contributor.authorSantos, Luana Nunes-
dc.contributor.authorMoise, Alexander R.-
dc.contributor.authorCastilo, Hozana Andrade-
dc.subjectTretinoínapt_BR
dc.subject.otherlanguageTretinoinpt_BR
dc.description.abstractRetinoic acid (RA) is a terpenoid that is synthesized from vitamin A/retinol (ROL) and binds to the nuclear receptors retinoic acid receptor (RAR)/retinoid X receptor (RXR) to control multiple developmental processes in vertebrates. The available clinical and experimental data provide uncontested evidence for the pleiotropic roles of RA signaling in development of multiple embryonic structures and organs such eyes, central nervous system, gonads, lungs and heart. The development of any of these above-mentioned embryonic organ systems can be effectively utilized to showcase the many strategies utilized by RA signaling. However, it is very likely that the strategies employed to transfer RA signals during cardiac development comprise the majority of the relevant and sophisticated ways through which retinoid signals can be conveyed in a complex biological system. Here, we provide the reader with arguments indicating that RA signaling is exquisitely regulated according to specific phases of cardiac development and that RA signaling itself is one of the major regulators of the timing of cardiac morphogenesis and differentiation. We will focus on the role of signaling by RA receptors (RARs) in early phases of heart developmentpt_BR
dc.relation.ispartofBiochimica et biophysica acta. Gene regulatory mechanismspt_BR
dc.publisher.cityAmsterdampt_BR
dc.publisher.countryPaíses Baixospt_BR
dc.publisherElsevierpt_BR
dc.date.issued2015-
dc.date.monthofcirculationFeb.pt_BR
dc.language.isoengpt_BR
dc.description.volume1849pt_BR
dc.description.issuenumber2pt_BR
dc.description.firstpage94pt_BR
dc.description.lastpage111pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn1874-9399pt_BR
dc.identifier.eissn1876-4320pt_BR
dc.identifier.doi10.1016/j.bbagrm.2014.08.003pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S1874939914002211pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumber481983/2013-9pt_BR
dc.description.sponsordocumentnumber2011/15273-7; 2012/14859-0; 2013/12008-6pt_BR
dc.date.available2021-02-05T00:38:49Z-
dc.date.accessioned2021-02-05T00:38:49Z-
dc.description.provenanceSubmitted by Sanches Olivia (olivias@unicamp.br) on 2021-02-05T00:38:49Z No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2021-02-05T00:38:49Z (GMT). No. of bitstreams: 0 Previous issue date: 2015en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/355277-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.subject.keywordRetinoic acidpt_BR
dc.subject.keywordHeart developmentpt_BR
dc.subject.keywordRARpt_BR
dc.subject.keywordRXRpt_BR
dc.subject.keywordALDH1A2pt_BR
dc.identifier.source000349272700004pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.type.formArtigo de revisãopt_BR
Appears in Collections:FCM - Artigos e Outros Documentos

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