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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampSilva, Vinícius Rodrigues-
dc.contributor.authorunicampHazell, Alan Stewart-
dc.typeArtigopt_BR
dc.titleAcute liver failure-induced hepatic encephalopathy is associated with changes in microRNA expression profiles in cerebral cortex of the ratpt_BR
dc.contributor.authorVemuganti, Raghu-
dc.contributor.authorSilva, Vinicius R.-
dc.contributor.authorMehta, Suresh L.-
dc.contributor.authorHazell, Alan S.-
dc.subjectEncefalopatia hepáticapt_BR
dc.subject.otherlanguageHepatic encephalopathypt_BR
dc.description.abstractThe mechanisms that promote brain dysfunction after acute liver failure (ALF) are not clearly understood. The small noncoding RNAs known as microRNAs (miRNAs) significantly control mRNA translation and thus normal and pathological functions in the mammalian body. To understand their significance in ALF, we currently profiled the expression of miRNAs in the cerebral cortex of mice sacrificed at coma stage following treatment with azoxymethane. Of the 470 miRNAs profiled using microarrays, 37 were significantly altered (20 up-and 17 down-regulated) in their expression in the ALF group compared to sham group. In silico analysis showed that the ALF-responsive miRNAs target on average 231 mRNAs/miRNA (range: 3 to 840 targets). Pathways analysis showed that many miRNAs altered after ALF target multiple mRNAs that are part of various biological and molecular pathways. Glutamatergic synapse, Wnt signaling, MAP-kinase signaling, axon guidance, PI3-kinase-AKT signaling, T-cell receptor signaling and ubiquitin-mediated proteolysis are the top pathways targeted by the ALF-sensitive miRNAs. At least 28 ALF-responsive miRNAs target each of the above pathways. We hypothesize that alterations in miRNAs and their down-stream mRNAs of signaling pathways might play a role in the induction and progression of neurological dysfunction observed during ALFpt_BR
dc.relation.ispartofMetabolic brain diseasept_BR
dc.relation.ispartofabbreviationMetab brain dispt_BR
dc.publisher.cityNew York, NYpt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherSpringerpt_BR
dc.date.issued2014-
dc.date.monthofcirculationDec.pt_BR
dc.language.isoengpt_BR
dc.description.volume29pt_BR
dc.description.issuenumber4pt_BR
dc.description.firstpage891pt_BR
dc.description.lastpage899pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0885-7490pt_BR
dc.identifier.eissn1573-7365pt_BR
dc.identifier.doi10.1007/s11011-014-9545-0pt_BR
dc.identifier.doi10.1007/s11011-014-9644-y-
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs11011-014-9545-0pt_BR
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs11011-014-9644-y-
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumber2011/02263-3; 2012/15660-3pt_BR
dc.date.available2021-02-04T20:31:15Z-
dc.date.accessioned2021-02-04T20:31:15Z-
dc.description.provenanceSubmitted by Sanches Olivia (olivias@unicamp.br) on 2021-02-04T20:31:15Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-05-25T12:08:29Z : No. of bitstreams: 1 000345287800002.pdf: 1696809 bytes, checksum: a5a7b8233acb1f21a566a5c240b8f0a6 (MD5). Added 1 bitstream(s) on 2021-05-25T12:08:32Z : No. of bitstreams: 2 000345287800002.pdf: 1696809 bytes, checksum: a5a7b8233acb1f21a566a5c240b8f0a6 (MD5) 000348053100030_Errata.pdf: 115853 bytes, checksum: 3e8d7dee97f67c5a86318e8bd35e9260 (MD5)en
dc.description.provenanceMade available in DSpace on 2021-02-04T20:31:15Z (GMT). No. of bitstreams: 0 Previous issue date: 2014en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/355268-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.subject.keywordLiver diseasept_BR
dc.subject.keywordmiRNApt_BR
dc.subject.keywordNon-codingRNApt_BR
dc.subject.keywordNeuroprotectionpt_BR
dc.subject.keywordMolecular signalingpt_BR
dc.identifier.source000345287800002pt_BR
dc.identifier.source000348053100030-
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcidsem informaçãopt_BR
dc.type.formArtigo de pesquisapt_BR
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