Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/355263
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampFreitas, Karine Moura-
dc.contributor.authorunicampAlmeida, Jacqueline Fátima Martins-
dc.contributor.authorunicampMonteiro, Juliana Castro-
dc.contributor.authorunicampVale, Jéssica Stephany Fernandes do-
dc.contributor.authorunicampCamargo, Camila de Andrade-
dc.typeArtigopt_BR
dc.titleThe effects of cyclosporin a and heteropterys tomentosa on the rat liverpt_BR
dc.contributor.authorde Freitas, Karine M.-
dc.contributor.authorAlmeida, Jacqueline M.-
dc.contributor.authorMonteiro, Juliana C.-
dc.contributor.authorDiamante, Maria Aparecida S.-
dc.contributor.authordo Vale, Jessica S. F.-
dc.contributor.authorCamargo, Camila-
dc.contributor.authorJorge, Marcal H. A.-
dc.contributor.authorDolder, Heidi-
dc.subjectFitoterapiapt_BR
dc.subjectHeteropterys aphrodisiacapt_BR
dc.subject.otherlanguageHeteropterys aphrodisiacapt_BR
dc.subject.otherlanguagePhytotherapypt_BR
dc.description.abstractCyclosporin A (CsA) is a widely employed immunosuppressive drug that is associated with several side effects, among then hepatotoxicity. Heteropterys tomentosa is a Brazilian plant efficient in reducing damage caused by CsA on the rat testis and prostate. The aim of this study was to evaluate the effect of CsA and H. tomentosa (administered isolated or simultaneously) on the liver of Wistar rats. The animals were treated daily with water (control), CsA (15mg/kg/day), H. tomentosa infusion or CsA+H. tomentosa, for 21 or 56 days. The treatments did not alter liver morphology or cause fibrosis. H. tomentosa administered for 21 days increased the number of hepatocyte nuclei and Kupffer cell volumetric proportion. After 56 days of treatment, H. tomentosa administration did not alter the parameters analyzed. Biochemical plasma dosages and liver stereology showed impairment caused by CsA-treatment after 21 days; these results were not observed after 56 days of treatment. The simultaneous treatment with CsA and H. tomentosa for 21 or 56 days did not alleviate nor accentuate CsA hepatic effects. The present study showed that the 21 days treatment with CsA caused more alteration to the liver than the 56 days treatment; this could be related to hepatic recovery after the long term treatmentpt_BR
dc.relation.ispartofAnais da Academia Brasileira de Ciênciaspt_BR
dc.relation.ispartofabbreviationAn. Acad. Bras. Ciênc.pt_BR
dc.publisher.cityRio de Janeiro, RJpt_BR
dc.publisher.countryBrasilpt_BR
dc.publisherAcademia Brasileira de Ciênciaspt_BR
dc.date.issued2015-
dc.date.monthofcirculationMar.pt_BR
dc.language.isoengpt_BR
dc.description.volume87pt_BR
dc.description.issuenumber1pt_BR
dc.description.firstpage369pt_BR
dc.description.lastpage379pt_BR
dc.rightsAbertopt_BR
dc.sourceSCIELOpt_BR
dc.identifier.issn0001-3765pt_BR
dc.identifier.eissn1678-2690pt_BR
dc.identifier.doi10.1590/0001-3765201520130351pt_BR
dc.identifier.urlhttps://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000100369pt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumber2011/01160-6pt_BR
dc.date.available2021-02-04T19:44:05Z-
dc.date.accessioned2021-02-04T19:44:05Z-
dc.description.provenanceSubmitted by Cintia Oliveira de Moura (cintiaom@unicamp.br) on 2021-02-04T19:44:05Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-05-25T14:38:12Z : No. of bitstreams: 1 S0001-37652015000100369.pdf: 1749550 bytes, checksum: c5a3c8ba04833bca1c7e0bb5c2518518 (MD5)en
dc.description.provenanceMade available in DSpace on 2021-02-04T19:44:05Z (GMT). No. of bitstreams: 0 Previous issue date: 2015en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/355263-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.identifier.sourceS0001-37652015000100369pt_BR
dc.creator.orcid0000-0002-7887-4600pt_BR
dc.creator.orcid0000-0003-0811-7652pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0002-0664-6617pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.type.formArtgopt_BR
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