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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampOzelo, Margareth Castro-
dc.typeArtigopt_BR
dc.titleImpact of severe haemophilia A on patients' health status: results from the guardian™ 1 clinical trial of turoctocog alfa (NovoEight®)pt_BR
dc.contributor.authorOzelo, M.-
dc.contributor.authorChowdary, P.-
dc.contributor.authorRegnault, A.-
dc.contributor.authorBusk, A. K.-
dc.subjectNível de saúdept_BR
dc.subject.otherlanguageHealth statuspt_BR
dc.description.abstractHaemophilia and its treatment interfere with patients' life and may affect adherence to treatment. This study explored the impact of severe haemophilia A on patients' health status, especially in young adults (YA), using data from guardian™ 1, a multinational, open‐label, non‐controlled phase 3 trial investigating safety and efficacy of turoctocog alfa (NovoEight®) in previously treated patients aged 12 years and older with severe haemophilia A (FVIII ≤ 1%). Health status was assessed using the EuroQoL‐5 dimensions (EQ‐5D‐3L), covering 5 dimensions of health (mobility, self‐care, usual activities, pain/discomfort and anxiety/depression), and a visual analogue scale (VAS) measuring self‐rated overall health status. EQ‐5D was administered pretreatment (screening/baseline) and posttreatment (end‐of‐trial). Baseline responses to the EQ‐5D dimensions and VAS were described overall and by age and compared to reference values from UK general population. Guardian™ 1 included 150 patients (16 adolescents, 83 YA aged 16–29 and 51 adults aged 30+). All five dimensions of patients' health status were impacted at baseline. The percentage of haemophilia patients reporting problems was consistently significantly greater than age‐matched general population reference values. Likewise, for all age groups mean baseline EQ‐5D VAS score was significantly lower for haemophilia patients (YA: 78.0) than for the general population (YA aged 18–29: 87.3). The health status of patients with severe haemophilia A entering guardian™ 1 was markedly poorer than that of the general population, particularly regarding mobility and pain. YA patients reported better health status than older patients, but considerably lower than that of the general YA populationpt_BR
dc.relation.ispartofHaemophiliapt_BR
dc.publisher.cityChichesterpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherWileypt_BR
dc.date.issued2015-
dc.date.monthofcirculationJulypt_BR
dc.language.isoengpt_BR
dc.description.volume21pt_BR
dc.description.issuenumber4pt_BR
dc.description.firstpage451pt_BR
dc.description.lastpage457pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn1351-8216pt_BR
dc.identifier.eissn1365-2516pt_BR
dc.identifier.doi10.1111/hae.12617pt_BR
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/10.1111/hae.12617pt_BR
dc.date.available2021-02-04T18:48:08Z-
dc.date.accessioned2021-02-04T18:48:08Z-
dc.description.provenanceSubmitted by Thais de Brito Barroso (tbrito@unicamp.br) on 2021-02-04T18:48:08Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-05-24T16:47:40Z : No. of bitstreams: 1 000356875600023.pdf: 296600 bytes, checksum: b0a3c85c275eafb085a9caee92f17c5c (MD5)en
dc.description.provenanceMade available in DSpace on 2021-02-04T18:48:08Z (GMT). No. of bitstreams: 0 Previous issue date: 2015en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/355255-
dc.contributor.departmentDepartamento de Clínica Médicapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.subject.keywordHaemophiliapt_BR
dc.subject.keywordProphylaxispt_BR
dc.subject.keywordQuestionnairespt_BR
dc.subject.keywordTuroctocog alfapt_BR
dc.identifier.source000356875600023pt_BR
dc.creator.orcid0000-0001-5938-0675pt_BR
dc.type.formArtigo originalpt_BR
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