Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/355241
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampBittar, Luis Fernando-
dc.contributor.authorunicampOrsi, Fernanda Loureiro de Andrade-
dc.contributor.authorunicampDe Paula, Erich Vinicius-
dc.contributor.authorunicampAnnichino-Bizzacchi, Joyce Maria-
dc.typeArtigopt_BR
dc.titleLong-term increased factor VIII levels are associated to interleukin-6 levels but not to post-thrombotic syndrome in patients with deep venous thrombosispt_BR
dc.contributor.authorBittar, Luis Fernando-
dc.contributor.authorMazetto, Bruna de Moraes-
dc.contributor.authorOrsi, Fernanda L. Andrade-
dc.contributor.authorCollela, Marina P.-
dc.contributor.authorDe Paula, Erich Vinicius-
dc.contributor.authorAnnichino-Bizzacchi, Joyce M.-
dc.subjectTrombose venosapt_BR
dc.subjectFator de von Willebrandpt_BR
dc.subject.otherlanguageVenous thrombosispt_BR
dc.subject.otherlanguagevon Willebrand factorpt_BR
dc.description.abstractIncreased FVIII levels are a well established risk factor for deep venous thrombosis (DVT), whose etiopathogenesis is not yet well understood. In this study, we aimed to evaluate the possibility that inflammatory markers and post-thrombotic syndrome (PTS) could contribute to FVIII levels in patients with a history of DVT. It is a case-control study that included 68 patients with DVT of the lower limbs 32 months after the acute episode, and 67 healthy adults as controls. We evaluated plasma levels of FVIII, VWF, D-dimer and serum levels of CRP, IL-6, IL-8, TNF-alpha in patients and controls. The presence of PTS was evaluated by the Villalta scale. Patients with DVT presented higher levels of FVIII, VWF and D-dimer when compared to controls (P <= 0.001). Almost 50% of patients presented FVIII levels above 90th percentile. Furthermore, IL-6 (1.19 vs. 0.98 pg/mL, P = 0.01) and TNF-alpha (2.27 vs. 1.57 pg/mL, P <= 0.001) were also higher in patients when compared to controls. In a linear regression multivariate model, VWF and IL-6 levels were independent factors associated with FVIII levels (P <= 0.001). FVIII levelswere not increased in patients with PTS. Patients with PTS showed higher levels of IL-8 when compared to patients without PTS (23.03 vs. 18.20 pg/mL, P = 0.04). In conclusion, we demonstrated that DVT is associated with increased levels of inflammatory and coagulation markers, including FVIII, even a long time after the acute episode. Moreover, IL-6 levels were an independent factor associated with FVIII levels. Finally, PTS seems to be related to inflammatory cytokine IL-8, a proinflammatory and proangiogenic chemokine, but not to FVIII levelspt_BR
dc.relation.ispartofThrombosis researchzpt_BR
dc.relation.ispartofabbreviationThromb. res.pt_BR
dc.publisher.cityOxfordpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherElsevierpt_BR
dc.date.issued2015-
dc.date.monthofcirculationMar.pt_BR
dc.language.isoengpt_BR
dc.description.volume135pt_BR
dc.description.issuenumber3pt_BR
dc.description.firstpage497pt_BR
dc.description.lastpage501pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0049-3848pt_BR
dc.identifier.eissn1879-2472pt_BR
dc.identifier.doi10.1016/j.thromres.2014.12.024pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0049384814006938pt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumber2009/53543-6pt_BR
dc.date.available2021-02-04T15:09:32Z-
dc.date.accessioned2021-02-04T15:09:32Z-
dc.description.provenanceSubmitted by Cintia Oliveira de Moura (cintiaom@unicamp.br) on 2021-02-04T15:09:32Z No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2021-02-04T15:09:32Z (GMT). No. of bitstreams: 0 Previous issue date: 2015en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/355241-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Patologia Clínicapt_BR
dc.contributor.departmentDepartamento de Patologia Clínicapt_BR
dc.contributor.departmentDepartamento de Clínica Médicapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.identifier.source000349633800011pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0002-7908-9073pt_BR
dc.creator.orcid0000-0003-1539-7912pt_BR
dc.creator.orcid0000-0002-1434-1071pt_BR
dc.type.formArtigopt_BR
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