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Type: Artigo
Title: Metabolic changes in masseter muscle of rats submitted to acute stress associated with exodontia
Author: Iyomasa, Mamie Mizusaki
Fernandes, Fernanda Silva
Iyomasa, Daniela Mizusaki
Lara Pereira, Yamba Carla
Restrepo Fernandez, Rodrigo Alberto
Calzzani, Ricardo Alexandre
Nascimento, Glauce Crivelaro
Andrade Leite-Panissi, Christie Ramos
Mardegan Issa, Joao Paulo
Abstract: Clinical evidence has shown that stress may be associated with alterations in masticatory muscle functions. Morphological changes in masticatory muscles induced by occlusal alterations and associated with emotional stress are still lacking in the literature. The objective of this study was to evaluate the influence of acute stress on metabolic activity and oxidative stress of masseter muscles of rats subjected to occlusal modification through morphological and histochemical analyses. In this study, adult Wistar rats were divided into 4 groups: a group with extraction and acute stress (E+A); group with extraction and without stress (E+C); group without extraction and with acute stress (NO+A); and control group without both extraction and stress (NO+C). Masseter muscles were analyzed by Succinate Dehydrogenase (SDH), Nicotinamide Adenine Dinucleotide Diaphorase (NADH) and Reactive Oxygen Species (ROS) techniques. Statistical analyses and two-way ANOVA were applied, followed by Tukey-Kramer tests. In the SDH test, the E+C, E+A and NO+A groups showed a decrease in high desidrogenase activities fibers (P < 0.05), compared to the NO+C group. In the NADH test, there was no difference among the different groups. In the ROS test, in contrast, E+A, E+C and NO+A groups showed a decrease in ROS expression, compared to NO+C groups (P < 0.05). Modified dental occlusion and acute stress - which are important and prevalent problems that affect the general population - are important etiologic factors in metabolic plasticity and ROS levels of masseter muscles
Subject: Transtornos da articulação temporomandibular
Músculo esquelético
Country: Estados Unidos
Editor: Public Library of Science
Rights: Aberto
Identifier DOI: 10.1371/journal.pone.0128397
Date Issue: 2015
Appears in Collections:FOP - Artigos e Outros Documentos

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