Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/355175
Full metadata record
DC FieldValueLanguage
dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampGuelsin, Gláucia Andréia Soares-
dc.contributor.authorunicampCampos, Paula de Melo-
dc.contributor.authorunicampTraina, Fabíola-
dc.contributor.authorunicampGilli, Simone Cristina Olenscki-
dc.contributor.authorunicampSaad, Sara Teresinha Olalla-
dc.contributor.authorunicampCastilho, Lilian Maria de-
dc.typeArtigopt_BR
dc.titleMolecular matching for Rh and K reduces red blood cell alloimmunisation in patients with myelodysplastic syndromept_BR
dc.contributor.authorGuelsin, Gláucia A. S.-
dc.contributor.authorRodrigues, Camila-
dc.contributor.authorVisentainer, Jeane E. L.-
dc.contributor.authorCampos, Paula de Melo-
dc.contributor.authorTraina, Fabíola-
dc.contributor.authorGilli, Simone C. O.-
dc.contributor.authorSaad, Sara T. O.-
dc.contributor.authorCastilho, Lilian-
dc.subjectAntígenos de grupos sanguíneospt_BR
dc.subject.otherlanguageBlood group antigenspt_BR
dc.description.abstractMatching for Rh and K antigens has been used in an attempt to reduce antibody formation in patients receiving chronic transfusions but an extended phenotype matching including Fya and Jka antigens has also been recommended. The aim of this study was to identify an efficient transfusion protocol of genotype matching for patients with myelodysplastic syndrome (MDS) or chronic myelomonocytic leukaemia. We also examined a possible association of HLA class II alleles with red blood cell (RBC) alloimmunisation. Materials and methods. We evaluated 43 patients with MDS undergoing transfusion therapy with and without antibody formation. We investigated antigen-matched RBC units for ABO, D, C, c, E, e, K, Fya, Fyb, Jka, Jkb, S, s, Doa, Dob and Dia on the patients' samples and on the donor units serologically matched for them based on their ABO, Rh and K phenotypes and presence of antibodies. We also determined the frequencies of HLA-DRB1 alleles in the alloimmunised and non-alloimmunised patients. Results. Seventeen of the 43 patients had discrepancies or mismatches for multiple antigens between their genotype-predicted profile and the antigen profile of the units of blood serologically matched for them. We verified that 36.8% of patients had more than one RBC alloantibody and 10.5% of patients had autoantibodies. Although we were able to find a better match for the patients in our extended genotyped/phenotyped units, we verified that matching for Rh and K would be sufficient for most of the patients. We also observed an over-representation of the HLA-DRB1*13 allele in the non-alloimmunised group of patients with MDS. Discussion. In our population molecular matching for C, c, E, e, K was able to reduce RBC alloimmunisation in MDS patients. An association of HLA-DRB1*13 and protection from RBC alloimmunisation should be confirmedpt_BR
dc.relation.ispartofBlood transfusionpt_BR
dc.relation.ispartofabbreviationBlood transfus.pt_BR
dc.publisher.cityMilanpt_BR
dc.publisher.countryItáliapt_BR
dc.publisherSIMTI Servizipt_BR
dc.date.issued2015-
dc.date.monthofcirculationJan./Mar.pt_BR
dc.language.isoengpt_BR
dc.description.volume13pt_BR
dc.description.firstpage53pt_BR
dc.description.lastpage58pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn1723-2007pt_BR
dc.identifier.eissn2385-2070pt_BR
dc.identifier.doi10.2450/2014.0332-13pt_BR
dc.identifier.urlhttp://www.bloodtransfusion.it/articolo.aspx?idart=002814pt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumber2010/06916-9; 2012/04651-3pt_BR
dc.date.available2021-02-03T12:45:49Z-
dc.date.accessioned2021-02-03T12:45:49Z-
dc.description.provenanceSubmitted by Thais de Brito Barroso (tbrito@unicamp.br) on 2021-02-03T12:45:49Z No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2021-02-03T12:45:49Z (GMT). No. of bitstreams: 0 Previous issue date: 2015en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/355175-
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentDepartamento de Clínica Médicapt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.unidadeCentro de Hematologia e Hemoterapiapt_BR
dc.contributor.unidadeCentro de Hematologia e Hemoterapiapt_BR
dc.contributor.unidadeCentro de Hematologia e Hemoterapiapt_BR
dc.contributor.unidadeCentro de Hematologia e Hemoterapiapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeCentro de Hematologia e Hemoterapiapt_BR
dc.subject.keywordHLA,pt_BR
dc.subject.keywordMolecular matchingpt_BR
dc.subject.keywordMyelodysplastic syndromept_BR
dc.subject.keywordRBC alloimmunisationpt_BR
dc.identifier.source000351423200008pt_BR
dc.creator.orcid0000-0003-0714-0690pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcid0000-0003-4258-289Xpt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcid0000-0003-0809-8068pt_BR
dc.creator.orcid0000-0002-3104-647Xpt_BR
dc.type.formArtigo originalpt_BR
Appears in Collections:FCM - Artigos e Outros Documentos
HEMO - Artigos e Outros Documentos

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.