Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/355156
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampPytlowanciv, Eloísa Zanin-
dc.contributor.authorunicampTaboga, Sebastião Roberto-
dc.contributor.authorunicampGóes, Rejane Maira-
dc.typeArtigopt_BR
dc.titleA high-fat diet fed during different periods of life impairs steroidogenesis of rat Leydig cellspt_BR
dc.contributor.authorPinto-Fochi, Maria Etelvina-
dc.contributor.authorPytlowanciv, Eloísa Zanin-
dc.contributor.authorReame, Vanessa-
dc.contributor.authorRafacho, Alex-
dc.contributor.authorRibeiro, Daniele Lisboa-
dc.contributor.authorTaboga, Sebastião Roberto-
dc.contributor.authorGóes, Rejane Maira-
dc.subjectLeydig, Células dept_BR
dc.subject.otherlanguageLeydig cellspt_BR
dc.description.abstractThis study evaluated the impact of a high-fat diet (HFD) during different stages of rat life, associated or not with maternal obesity, on the content of sex steroid hormones and morphophysiology of Leydig cells. The following periods of development were examined: gestation (O1), gestation and lactation (O2), from weaning to adulthood (O3), from lactation to adulthood (O4), gestation to adulthood (O5), and after sexual maturation (O6). The HFD contained 20% unsaturated fat, whereas the control diet had 4% fat. Maternal obesity was induced by feeding HFD 15 weeks before mating. All HFD groups presented increased body weight, hyperinsulinemia and reduced insulin sensitivity. Except for O1, all HFD groups exhibited a higher adiposity index, hyperleptinemia, reduced testosterone and estradiol testicular levels, and decreased testicular 17β-HSD enzyme . Morphometrical analyses indicated atrophy of Leydig cells in the O2 group. Myelin vesicles were observed in the mitochondrial matrix of Leydig cells in O3, O4, O5 and O6, and autophagosomes containing mitochondria were found in O5 and O6. In conclusion, HFD feeding, before or after sexual maturation, reduces the functional capacity of rat Leydig cells. Maternal obesity associated with HFD during pregnancy/lactation prejudices Leydig cell steroidogenesis and induces its atrophy in adulthood, even if it is replaced by a conventional diet at later stages of life. Regardless of the life period of exposure to HFD, deregulation of leptin is the main factor related to steroidogenic impairment of Leydig cells, and, in groups exposed for longer periods (O3, O4, O5 and O6), this is worsened by structural damage and mitochondrial degeneration of these cells.pt_BR
dc.relation.ispartofReproductionpt_BR
dc.publisher.cityBristolpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherBioscientificapt_BR
dc.date.issued2016-
dc.date.monthofcirculationDec.pt_BR
dc.language.isoengpt_BR
dc.description.volume152pt_BR
dc.description.issuenumber6pt_BR
dc.description.firstpage795pt_BR
dc.description.lastpage808pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn1470-1626pt_BR
dc.identifier.eissn1741-7899pt_BR
dc.identifier.doi10.1530/REP-16-0072pt_BR
dc.identifier.urlhttps://rep.bioscientifica.com/view/journals/rep/152/6/795.xmlpt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumber306258/2011pt_BR
dc.description.sponsordocumentnumber2011/01612-4; 2009/16071-9; 2011/03596-6; 2013/18011-9pt_BR
dc.date.available2021-02-02T19:33:20Z-
dc.date.accessioned2021-02-02T19:33:20Z-
dc.description.provenanceSubmitted by Bruna Maria Campos da Cunha (bcampos@unicamp.br) on 2021-02-02T19:33:20Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-05-21T19:46:39Z : No. of bitstreams: 1 000387771600026.pdf: 2834110 bytes, checksum: cb3a5ef3007b00d07eb7845e1208e318 (MD5)en
dc.description.provenanceMade available in DSpace on 2021-02-02T19:33:20Z (GMT). No. of bitstreams: 0 Previous issue date: 2016en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/355156-
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.identifier.source000387771600026pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcid0000-0002-0970-4288pt_BR
dc.creator.orcid0000-0002-3622-460Xpt_BR
dc.type.formArtigopt_BR
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