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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampDias, Fernando Goulart Fernandes-
dc.typeArtigopt_BR
dc.titleEffects of immunosuppression with tacrolimus and mycophenolate mofetil on renal histology and function in single kidney rats submitted to ischemia and reperfusionpt_BR
dc.contributor.authorGoulart Fernandes Dias, Paulo Henrique-
dc.contributor.authorOliveira, Gabriel Augusto-
dc.contributor.authorFernandes Dias, Fernando Goulart-
dc.contributor.authorXavier Gomes, Regina de Paula-
dc.contributor.authorTambara Filho, Renato-
dc.contributor.authorde Fraga, Rogerio-
dc.subjectImunossupressãopt_BR
dc.subjectTacrolimopt_BR
dc.subjectReperfusãopt_BR
dc.subjectIsquemiapt_BR
dc.subject.otherlanguageImmunosuppressionpt_BR
dc.subject.otherlanguageTacrolimuspt_BR
dc.subject.otherlanguageIschemiapt_BR
dc.subject.otherlanguageReperfusãopt_BR
dc.description.abstractTo evaluate renal histological changes and renal function in single kidney rats submitted to renal ischemia-reperfusion and to immunosuppression with tacrolimus and mycophenolate-mofetil. Experimental study with 80 Wistar rats distributed into control, Sham and six other groups treated with immunosuppressive drugs. Animals undergoing surgery, right nephrectomy and left renal clamping, killed on the 14th day and analyzed for renal histology, urea and creatinine. The group receiving tacrolimus at higher doses (T3) showed renal histological lesions indicative of early nephrotoxicity, and significant increase in urea and creatinine. The group M (mycophenolate-mofetil alone) and the group M2 (mycophenolate-mofetil combined with half the usual dose of tacrolimus) presented a slight rise in serum urea. The groups using mycophenolate-mofetil alone or combined with tacrolimus showed creatinine levels similar to that of the group T3. Histologically, the association of injury by ischemia-reperfusion with the use of tacrolimus or mycophenolatemofetil alone demonstrated a higher rate of renal changes typical of early nephrotoxicity. In laboratory, the combination of injury by ischemia-reperfusion with tacrolimus at higher doses proved to be nephrotoxicpt_BR
dc.relation.ispartofActa cirurgica brasileirapt_BR
dc.relation.ispartofabbreviationActa cir. bras.pt_BR
dc.publisher.citySão Paulo, SPpt_BR
dc.publisher.countryBrasilpt_BR
dc.publisherSociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgiapt_BR
dc.date.issued2015-
dc.date.monthofcirculationFeb.pt_BR
dc.language.isoengpt_BR
dc.description.volume30pt_BR
dc.description.issuenumber2pt_BR
dc.description.firstpage127pt_BR
dc.description.lastpage133pt_BR
dc.rightsAbertopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0102-8650pt_BR
dc.identifier.eissn1678-2674pt_BR
dc.identifier.doi10.1590/S0102-86502015002000007pt_BR
dc.identifier.urlhttps://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502015000200127pt_BR
dc.date.available2021-02-02T15:15:19Z-
dc.date.accessioned2021-02-02T15:15:19Z-
dc.description.provenanceSubmitted by Cintia Oliveira de Moura (cintiaom@unicamp.br) on 2021-02-02T15:15:19Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-05-25T14:37:46Z : No. of bitstreams: 1 000350333000007.pdf: 577112 bytes, checksum: e99bd3ad7a00d1b75ee7d6b6662efc02 (MD5)en
dc.description.provenanceMade available in DSpace on 2021-02-02T15:15:19Z (GMT). No. of bitstreams: 0 Previous issue date: 2015en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/355118-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.identifier.source000350333000007pt_BR
dc.creator.orcid0000-0001-8494-4487pt_BR
dc.type.formArtigo originalpt_BR
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