Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/355107
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampLacchini, Riccardo-
dc.contributor.authorunicampBelo, Vanessa de Almeida-
dc.contributor.authorunicampSertorio, Jonas Tadeu Cau-
dc.contributor.authorunicampTanus-Santos, Jose Eduardo-
dc.typeArtigopt_BR
dc.titleThe effects of endothelial nitric oxide synthase tagSNPs on nitrite levels and risk of hypertension and obesity in children and adolescentspt_BR
dc.contributor.authorde Miranda, J. A.-
dc.contributor.authorLacchini, R.-
dc.contributor.authorBelo, V. A.-
dc.contributor.authorLanna, C. M. M.-
dc.contributor.authorSertorio, J. T.-
dc.contributor.authorLuizon, M. R.-
dc.contributor.authorTanus-Santos, J. E.-
dc.subjectAdiponectinapt_BR
dc.subjectDiabetes mellitus tipo 2pt_BR
dc.subject.otherlanguageDiabetes mellitus, Type 2pt_BR
dc.subject.otherlanguageAdiponectinpt_BR
dc.description.abstractObesity and the nitric oxide synthase 3 (NOS3) gene polymorphisms are associated with nitrite levels and hypertension. However, no study has tested the hypothesis that NOS3 tagSNPs rs3918226, rs3918188, rs743506 and rs7830 affect nitrite levels and are associated with hypertension in childhood obesity. We investigated the association of these NOS3 tagSNPs and the haplotypes formed by them with hypertension and with nitrite levels in children and adolescents with obesity and with obesity plus hypertension. We studied 355 subjects: 174 healthy (controls), 109 normotensive obese, and 72 obese children and adolescents with obesity plus hypertension. Genotypes were determined by Taqman allele discrimination assay and real-time PCR. We compared the distribution of NOS3 tagSNP genotypes, alleles and haplotypes in the three groups of subjects. Nitrite levels were determined by ozone-based chemiluminescence. Nitrite levels were affected by the rs3918226 polymorphism (P<0.05) but not by NOS3 haplotypes. There was no association between the tagSNPs studied and hypertension in children and adolescents. Our findings show that the NOS3 tagSNP rs3918226 is associated with NO production in children and adolescents, and suggest that this polymorphism may have an impact on cardiovascular health. Further studies are needed to better clarify the effects of this polymorphism on cardiovascular riskpt_BR
dc.relation.ispartofJournal of human hypertensionpt_BR
dc.relation.ispartofabbreviationJ. hum. hypertens.pt_BR
dc.publisher.cityLondonpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherNature Publishing Grouppt_BR
dc.date.issued2015-
dc.date.monthofcirculationFeb.pt_BR
dc.language.isoengpt_BR
dc.description.volume29pt_BR
dc.description.issuenumber2pt_BR
dc.description.firstpage109pt_BR
dc.description.lastpage114pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0950-9240pt_BR
dc.identifier.eissn1476-5527pt_BR
dc.identifier.doi10.1038/jhh.2014.48pt_BR
dc.identifier.doi10.1038/jhh.2014.69pt_BR
dc.identifier.urlhttps://www.nature.com/articles/jhh201448pt_BR
dc.identifier.urlhttps://www.nature.com/articles/jhh201469pt_BR
dc.date.available2021-02-02T14:12:48Z-
dc.date.accessioned2021-02-02T14:12:48Z-
dc.description.provenanceSubmitted by Cintia Oliveira de Moura (cintiaom@unicamp.br) on 2021-02-02T14:12:48Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-05-25T14:37:37Z : No. of bitstreams: 1 000347674300008.pdf: 245871 bytes, checksum: 06dd259e97fb8996b8caf661e3435198 (MD5). Added 1 bitstream(s) on 2021-05-25T14:37:39Z : No. of bitstreams: 2 000347674300008.pdf: 245871 bytes, checksum: 06dd259e97fb8996b8caf661e3435198 (MD5) 000347674300016.pdf: 129366 bytes, checksum: 94307373e186d5a47f61bb3a1402b3fa (MD5)en
dc.description.provenanceMade available in DSpace on 2021-02-02T14:12:48Z (GMT). No. of bitstreams: 0 Previous issue date: 2015en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/355107-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.identifier.source000347674300008pt_BR
dc.identifier.source000347674300016pt_BR
dc.creator.orcid0000-0002-3738-2036pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0002-9945-9633pt_BR
dc.type.formArtigo originalpt_BR
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