Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/354999
Type: Artigo
Title: Fat gain with physical detraining is correlated with increased glucose transport and oxidation in periepididymal white adipose tissue in rats
Author: Sertie, R. A. L.
Andreotti, S.
Proenca, A. R. G.
Campana, A. B.
Lima, F. B.
Abstract: As it is a common observation that obesity tends to occur after discontinuation of exercise, we investigated how white adipocytes isolated from the periepididymal fat of animals with interrupted physical training transport and oxidize glucose, and whether these adaptations support the weight regain seen after 4 weeks of physical detraining. Male Wistar rats (45 days old, weighing 200 g) were divided into two groups (n=10): group D (detrained), trained for 8 weeks and detrained for 4 weeks; and group S (sedentary). The physical exercise was carried out on a treadmill for 60 min/day, 5 days/week for 8 weeks, at 50-60% of the maximum running capacity. After the training protocol, adipocytes isolated from the periepididymal adipose tissue were submitted to glucose uptake and oxidation tests. Adipocytes from detrained animals increased their glucose uptake capacity by 18.5% compared with those from sedentary animals (P<0.05). The same cells also showed a greater glucose oxidation capacity in response to insulin stimulation (34.55%) compared with those from the S group (P<0.05). We hypothesize that, owing to the more intense glucose entrance into adipose cells from detrained rats, more substrate became available for triacylglycerol synthesis. Furthermore, this increased glucose oxidation rate allowed an increase in energy supply for triacylglycerol synthesis. Thus, physical detraining might play a role as a possible obesogenic factor for increasing glucose uptake and oxidation by adipocytes
Subject: Adipócitos
Lipogênese
Country: Brasil
Editor: Associação Brasileira de Divulgação Científica
Rights: Aberto
Identifier DOI: 10.1590/1414-431X20154356
Address: https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000700650
Date Issue: 2015
Appears in Collections:FCA - Artigos e Outros Documentos

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